PMID: 3753033Jan 1, 1986Paper

Differential analysis of experimental hypermelanosis induced by UVB, PUVA, and allergic contact dermatitis using a brownish guinea pig model

Archives of Dermatological Research
G ImokawaI Motegi

Abstract

In moderately colored guinea-pig skin, UVB, PUVA, and allergic contact dermatitis were shown to induce hyperpigmentation that resembled the pigmentary changes observed in mongoloid human skin. Using this model, we examined the effects of chemical agents, including tyrosinase inhibitors and sunscreen agents, on the color changes induced by UV irradiation. The daily exposure of brownish guinea-pig skin to UVB irradiation at a variety of energies for 3 successive days induced clearly visible black pigmentation on the irradiated rectangular areas of the flank within a few days of irradiation, the maximum being reached about 1 week after irradiation, i.e., similar to the changes that occur in pigmented human skin. Split epidermal sheets prepared from untreated pigmented guinea pigs exhibited 200-400 melanocytes/mm2; 1 week after UV irradiation, the applied areas show an increased number of strongly dopa-positive melanocytes with stout dendrites (800-1,000 cells/mm2). UVA irradiation following an intraperitoneal injection of 8-methoxypsoralen (8-MOP) also produced black pigmentation 1 week after irradiation, and this was paralleled by a marked increase in the number of dopa-positive melanocytes in dopa-reacted split epidermal sheets....Continue Reading

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Citations

Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·D A Brown
Sep 1, 1990·Pigment Cell Research·J L BologniaJ M Pawelek
Jun 17, 2003·Biological & Pharmaceutical Bulletin·Sook-Jung ImWon-Hong Woo
Apr 2, 2004·Biological & Pharmaceutical Bulletin·Yasutami ShigetaTaketoshi Makino
May 3, 2008·Biological & Pharmaceutical Bulletin·Yeon Hee KongSang Yoon Choi
Mar 3, 2009·Biological & Pharmaceutical Bulletin·Kimihisa ItohHideaki Matsuda
Dec 9, 2008·Bioscience, Biotechnology, and Biochemistry·Takayuki HanamuraHitoshi Aoki
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Feb 14, 2002·The Journal of Investigative Dermatology·Masaki YoshidaYasushi Tomita
Dec 24, 2005·The Journal of Investigative Dermatology·Maritza A Middelkamp-HupSalvador Gonzalez
Jul 21, 2005·Pigment Cell Research·Megumi TobiishiMasako Mizoguchi
Mar 21, 2007·Pigment Cell Research·Tae-Young ChoiTae-Jin Yoon
Oct 1, 1988·The British Journal of Dermatology·B BertauxL Dubertret
Sep 1, 2011·Toxicological Research·So-Young Choi, Young-Chul Kim
Aug 30, 2006·Biochemical and Biophysical Research Communications·Sang Yoon ChoiSun Yeou Kim
Nov 27, 2007·The Journal of Investigative Dermatology·Jin Hee KimChoong Hwan Lee
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Apr 14, 2020·Environmental and Molecular Mutagenesis·Soumyadeep Sarkar, Shobhan Gaddameedhi
Nov 16, 2004·Pigment Cell Research·Megumi TobiishiMasako Mizoguchi
Jun 16, 2001·The Journal of Investigative Dermatology·Y KawaguchiA Nakayama
Jan 1, 1993·The Journal of Investigative Dermatology·G Imokawa, I Motegi

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