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Differential analysis of gene regulation at transcript resolution with RNA-seq

Nature Biotechnology

Jan 1, 2013

Cole TrapnellLior Pachter

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Abstract

Differential analysis of gene and transcript expression using high-throughput RNA sequencing (RNA-seq) is complicated by several sources of measurement variability and poses numerous statistical challenges. We present Cuffdiff 2, an algorithm that estimates expression at transcript-leve...read more

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    • References50
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    • Citations559
  • Differential analysis of gene regulation at transcript resolution with RNA-seq

    Nature Biotechnology

    Jan 1, 2013

    Cole TrapnellLior Pachter

    PMID: 23222703

    DOI: 10.1038/nbt.2450

    Abstract

    Differential analysis of gene and transcript expression using high-throughput RNA sequencing (RNA-seq) is complicated by several sources of measurement variability and poses numerous statistical challenges. We present Cuffdiff 2, an algorithm that estimates expression at transcript-leve...read more

    61
    3
    3038
    1
    2

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    • Citations559
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