Differential and strain-specific triggering of bovine alveolar macrophage effector functions by mycoplasmas

Microbial Pathogenesis
T W JungiJ Nicolet

Abstract

Mycoplasma strains being considered as pathogenic or non-pathogenic for cattle were tested on their capacity to activate bovine alveolar macrophages in vitro. Of particular interest was the behaviour of Mycoplasma mycoides ssp. mycoides small colony type (M.m.m. SC), the causative agent of contagious bovine pleuropneumonia (CBPP). Increases in procoagulant activity (PCA), tumor necrosis factor-alpha- (TNF-alpha) and nitrogen monoxide (NO) generation were tested. To minimize an influence of macrophage activation by mycoplasma growth media, mycoplasmas were cultured on embryonic calf nose epithelial cells. The three macrophage functions tested were not correlated, but were differentially induced in strain-specific manner. Four out of seven strains induced PCA, regardless of pathogenicity, and all strains promoted moderate NO generation at high concentrations. All tested M.m.m. SC strains (Afadé, L2 and PG1), and the pathogenic M. bovis, induced TNF-alpha production at low concentrations (10(6) colony forming units per ml). M.sp. serogroup 7 and the non-pathogenic M. bovirhinis and Acholeplasma laidlawii did not induce TNF-alpha up to 10(8) cfu/ml. Thus, strain-specific differences are reflected in differential macrophage activati...Continue Reading

Citations

Aug 18, 2010·Infection and Immunity·Jacques van der MerweJose Perez-Casal
Jan 17, 2015·Veterinary Immunology and Immunopathology·Hussain A AlabdullahRobert H Mealey
Mar 29, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Mihai I GageaJeff L Caswell
Jan 26, 2008·Animal Health Research Reviews·Jeff L Caswell, Marie Archambault
Jul 13, 2011·Journal of Veterinary Internal Medicine·F P MaunsellE D Janzen
May 12, 2020·Veterinary Pathology·Giovanni Di TeodoroMassimo Scacchia
Nov 18, 2014·Reproduction in Domestic Animals = Zuchthygiene·F Rodríguez, P Castro
Oct 23, 2015·Veterinary Research·Philippe TottéFrançois Thiaucourt
Oct 22, 2014·Veterinary Research Communications·Francisco RodríguezAntonio Fernández
Jan 11, 2018·Veterinary Research·Nina BürgiPaola Pilo
May 28, 2020·Pathogens·Katarzyna DudekStanisław Winiarczyk
Sep 30, 2017·FEMS Microbiology Reviews·Cedric Blötz, Jörg Stülke
Feb 1, 2002·FEMS Immunology and Medical Microbiology·Tony J Vanden Bush, Ricardo F Rosenbusch
Apr 4, 2021·Pathogens·Hussam AskarYuefeng Chu
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·S RazinY Naot
Aug 26, 1998·Infection and Immunity·R W StichW C Brown
Jan 29, 2009·The Veterinary Clinics of North America. Food Animal Practice·Fiona P Maunsell, G Arthur Donovan

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