PMID: 9428696Jan 15, 1998Paper

Differential androgen regulation of the murine genes for cysteine-rich secretory proteins (CRISP)

European Journal of Biochemistry
B HaendlerW D Schleuning

Abstract

The androgen dependency of the genes coding for the cysteine-rich secretory proteins (CRISP) was analysed in their main sites of expression. Male mice were treated with the gonadotropin-releasing hormone antagonist Ac-DNapAla-DClPhAla-DPyrAla-Ser-Tyr-DCtl-Leu-Lys (Mor)-Pro-DAla-NH2 [DNapAla, D-2-naphthyl-Ala; DClPhAla, D-4-chlorphenyl-Ala; DPyrAla, D-pyridyn-3-yl-Ala; DCtl, D-citrulline; Lys(Mor), L-2-amino-6-(morpholin-4-yl)-hexanoic acid], and CRISP RNA levels were assessed by northern blot and competitive reverse transcriptase-mediated (RT)-PCR. In the salivary gland, CRISP-1 and to a lesser extent CRISP-3 expression was markedly reduced, in spite of an up-regulation of androgen receptor transcript levels. A down-regulation of CRISP-1 expression was also observed in the epididymis. Conversely, the levels of the testicular CRISP-2 transcripts were hardly affected at all. Female mice were ovariectomised and treated with testosterone propionate, and their salivary gland RNAs analysed. CRISP-1 and CRISP-3 RNA levels were significantly increased, and these effects were prevented by a concomitant treatment with the antiandrogen flutamide. Androgen receptor transcript levels were not affected by androgen administration but increase...Continue Reading

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Citations

Feb 16, 1999·Journal of Cellular Physiology·B HaendlerW D Schleuning
Jan 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hellmuth-Alexander MeyerBernard Haendler
Jul 18, 2002·Gene·Alexander GieseTosso Leeb
Dec 24, 2010·Molecular & Cellular Proteomics : MCP·JianYuan LiHaiYan Wang
Aug 16, 2008·Biology of Reproduction·Kenneth P RobertsDavid W Hamilton
Oct 26, 2010·Asian Journal of Andrology·Adam J KoppersMoira K O'Bryan
Jun 26, 2007·Asian Journal of Andrology·Kenneth P RobertsDavid W Hamilton
Oct 17, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Thulasimala ReddyMoira K O'Bryan
Sep 26, 2007·Annals of the New York Academy of Sciences·Pauliina PorolaYrjö T Konttinen
Jan 18, 2006·Molecular and Cellular Endocrinology·Kenneth P RobertsDavid W Hamilton
Dec 30, 2014·Fertility and Sterility·Shih-Hsing LeirAnn Harris
Aug 22, 2008·Biology of Reproduction·Melissa L VadnaisKenneth P Roberts
Feb 10, 2012·Molecular Biology and Evolution·Kartik SunagarAgostinho Antunes
May 8, 2020·Human Reproduction Update·Avinash S GaikwadMoira K O'Bryan
Feb 15, 2003·Endocrinology·Nadine Ezer, Bernard Robaire
Aug 23, 2012·American Journal of Physiology. Endocrinology and Metabolism·Nina TrokovicYrjö T Konttinen

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