Differential antagonism of cocaine self-administration and cocaine-induced disruptions of learning by haloperidol in rhesus monkeys.

Journal of the Experimental Analysis of Behavior
Peter J WinsauerAlison M Roussell

Abstract

Six rhesus monkeys responding under a three-component multiple schedule were administered haloperidol to determine its effects on cocaine self-administration and on cocaine's disruptive effects on the repeated acquisition and performance of response chains. In the absence of haloperidol, 0.0032-0.032 mg/kg/infusion of cocaine increased response rate and the number of infusions in the self-administration component when compared to saline administration, whereas 0.1-0.32 mg/kg/infusion decreased response rate and the number of infusions. When compared to saline administration, the two lowest infusion doses of cocaine had little or no effect on responding in the acquisition and performance components; however, higher infusion doses of cocaine dose-dependently decreased response rate in these components. In addition, the higher doses of cocaine also increased the percentage of errors in the acquisition and performance components. Pretreatment with haloperidol (0.0032 or 0.01 mg/kg, i.m.) antagonized the effects of low doses of cocaine on the number of infusions in the self-administration component, whereas only the 0.01-mg/kg dose antagonized the effects of high doses of cocaine on the number of infusions. Neither dose of haloperid...Continue Reading

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Citations

Jul 16, 2010·Journal of Clinical Psychopharmacology·Simon ZhornitskyStéphane Potvin
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Albert GjeddeArne Møller
Jul 13, 2016·Journal of the Experimental Analysis of Behavior·Richard A Meisch, Thomas H Gomez

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