Abstract
Coronary artery calcium score (CACS) is a strong predictor of major adverse cardiac events (MACE). Conversely, statins, which markedly reduce MACE risk, increase CACS. We explored whether CACS progression represents compositional plaque volume (PV) progression differently according to statin use. From a prospective multinational registry of consecutive patients (n = 2252) who underwent serial coronary computed tomography angiography (CCTA) at a ≥ 2-year interval, 654 patients (61 ± 10 years, 56% men, inter-scan interval 3.9 ± 1.5 years) with information regarding the use of statins and having a serial CACS were included. Patients were divided into non-statin (n = 246) and statin-taking (n = 408) groups. Coronary PVs (total, calcified, and non-calcified; sum of fibrous, fibro-fatty, and lipid-rich) were quantitatively analysed, and CACS was measured from both CCTAs. Multivariate linear regression models were constructed for both statin-taking and non-statin group to assess the association between compositional PV change and change in CACS. In multivariate linear regression analysis, in the non-statin group, CACS increase was positively associated with both non-calcified (β = 0.369, P = 0.004) and calcified PV increase (β = 1.579...Continue Reading
References
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Dec 31, 1998·The New England Journal of Medicine·T Q CallisterD J Russo
Apr 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Paolo RaggiLeslee J Shaw
Aug 25, 2004·The American Journal of Cardiology·Nathan D WongRobert Detrano
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN CAMELOT Investigators
Jun 24, 2005·Radiology·Robert C DetranoDiane E Bild
Jul 13, 2005·Circulation·Paolo RaggiJohn A Rumberger
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Aug 7, 2008·European Heart Journal·Gabija PundziuteJeroen J Bax
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Dec 18, 2010·JACC. Cardiovascular Imaging·Matthew J BudoffPaolo Raggi
Apr 27, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gary S MintzPatrick W Serruys
Aug 10, 2011·Investigative Radiology·Maiken Glud DalagerHans Erik Bøtker
Feb 22, 2012·JACC. Cardiovascular Imaging·Kousuke HattoriJagat Narula
Mar 21, 2012·JACC. Cardiovascular Imaging·Stella-Lida PapadopoulouPim J de Feyter
Feb 19, 2013·The International Journal of Cardiovascular Imaging·Michiel A de GraafArthur J Scholte
Mar 19, 2013·Journal of the American College of Cardiology·Matthew J BudoffNathan D Wong
Sep 3, 2013·European Heart Journal·UNKNOWN Task Force MembersJose Luis Zamorano
Nov 14, 2013·Circulation·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Nov 20, 2013·JAMA : the Journal of the American Medical Association·Michael H CriquiMatthew A Allison
Jan 23, 2014·European Heart Journal Cardiovascular Imaging·Rishi PuriStephen J Nicholls
Oct 11, 2014·Journal of Cardiovascular Computed Tomography·Jonathon LeipsicGilbert L Raff
Jan 13, 2015·European Heart Journal·Peter Libby
Apr 4, 2015·Journal of the American College of Cardiology·Rishi PuriSteven E Nissen
Apr 4, 2015·Journal of the American College of Cardiology·Leslee J ShawY Chandrashekhar
May 23, 2015·European Radiology·Hyung-Bok ParkNamsik Chung
Jul 25, 2015·Journal of the American College of Cardiology·Sadako MotoyamaJagat Narula
Sep 17, 2016·Radiology·Rolf SymonsDavid A Bluemke
Oct 27, 2016·Journal of Cardiovascular Computed Tomography·Suhny AbbaraJonathon Leipsic
Dec 5, 2016·American Heart Journal·Sang-Eun LeeJames K Min
Oct 23, 2017·JACC. Cardiovascular Imaging·Indre CeponieneMatthew J Budoff
Nov 17, 2017·Circulation·Nils LehmannUNKNOWN Heinz Nixdorf Recall Study Investigators
Jun 18, 2018·JACC. Cardiovascular Imaging·Sang-Eun LeeJames K Min
Oct 22, 2018·Journal of Cardiovascular Computed Tomography·Sang-Eun LeeHyuk-Jae Chang
Citations
Mar 18, 2019·European Heart Journal Cardiovascular Imaging·Maros FerencikKhurram Nasir
Oct 24, 2019·European Heart Journal Cardiovascular Imaging·Gerald Maurer
Nov 9, 2019·European Heart Journal Cardiovascular Imaging·Marcio H MinameRaul D Santos
Jul 11, 2020·Current Opinion in Cardiology·Karan KapoorKhurram Nasir
Aug 11, 2020·Current Opinion in Lipidology·Apurba ChakrabartiNadia R Sutton
Sep 2, 2020·Current Atherosclerosis Reports·Jing PangGerald F Watts
Jan 8, 2020·Nutrients·Liv M VossenPeter W de Leeuw
Jan 7, 2020·European Heart Journal·Dudley PennellJeroen J Bax
Oct 24, 2019·European Heart Journal Cardiovascular Imaging·Filippo Cademartiri
Sep 16, 2020·European Heart Journal Cardiovascular Imaging·Thor EdvardsenBernard Cosyns
Dec 9, 2020·Scientific Reports·Ki-Bum WonHyuk-Jae Chang
Jan 4, 2021·European Heart Journal·José Luis ZamoranoChiara Bucciarelli-Ducci
Jan 18, 2021·JACC. Cardiovascular Imaging·Girish Dwivedi, Biyanka Jaltotage
Apr 7, 2020·Journal of Thoracic Imaging·Stefan BaumannDaniel Overhoff
Mar 12, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Anton G KutikhinGuido Krenning
Apr 4, 2021·Journal of Clinical Medicine·Isabel Aguilar-PalacioJosé Antonio Casasnovas
Oct 10, 2020·Journal of Cardiovascular Computed Tomography·Minkwan KimHyuk-Jae Chang
May 16, 2021·Clinical Imaging·Aydan Avdan AslanMehmet Araç
Jul 31, 2021·Journal of Cardiovascular Computed Tomography·Michelle C WilliamsHarvey Hecht
Aug 19, 2021·JAMA Cardiology·Alexander R van RosendaelHyuk-Jae Chang
Aug 26, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Xi HuBin Chen
Jan 9, 2022·European Radiology·F Y van DriestJ W Jukema