Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study

European Heart Journal Cardiovascular Imaging
Sang-Eun LeeHyuk-Jae Chang

Abstract

Coronary artery calcium score (CACS) is a strong predictor of major adverse cardiac events (MACE). Conversely, statins, which markedly reduce MACE risk, increase CACS. We explored whether CACS progression represents compositional plaque volume (PV) progression differently according to statin use. From a prospective multinational registry of consecutive patients (n = 2252) who underwent serial coronary computed tomography angiography (CCTA) at a ≥ 2-year interval, 654 patients (61 ± 10 years, 56% men, inter-scan interval 3.9 ± 1.5 years) with information regarding the use of statins and having a serial CACS were included. Patients were divided into non-statin (n = 246) and statin-taking (n = 408) groups. Coronary PVs (total, calcified, and non-calcified; sum of fibrous, fibro-fatty, and lipid-rich) were quantitatively analysed, and CACS was measured from both CCTAs. Multivariate linear regression models were constructed for both statin-taking and non-statin group to assess the association between compositional PV change and change in CACS. In multivariate linear regression analysis, in the non-statin group, CACS increase was positively associated with both non-calcified (β = 0.369, P = 0.004) and calcified PV increase (β = 1.579...Continue Reading

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Citations

Mar 18, 2019·European Heart Journal Cardiovascular Imaging·Maros FerencikKhurram Nasir
Oct 24, 2019·European Heart Journal Cardiovascular Imaging·Gerald Maurer
Jul 11, 2020·Current Opinion in Cardiology·Karan KapoorKhurram Nasir
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Oct 10, 2020·Journal of Cardiovascular Computed Tomography·Minkwan KimHyuk-Jae Chang
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Aug 19, 2021·JAMA Cardiology·Alexander R van RosendaelHyuk-Jae Chang
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