Differential Atrophy of Hippocampal Subfields: A Comparative Study of Dementia with Lewy Bodies and Alzheimer Disease

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Elijah MakJohn T O'Brien

Abstract

Dementia with Lewy bodies (DLB) is characterized by relative preservation of the medial temporal lobe compared with Alzheimer disease (AD). The differential involvement of the hippocampal subfields in both diseases has not been clearly established, however. We aim to investigate hippocampal subfield differences in vivo in a clinical cohort of DLB and AD subjects. 104 participants (35 DLBs, 36 ADs, and 35 healthy comparison [HC] subjects) underwent clinical assessment and 3T T1-weighted imaging. A Bayesian model implemented in Freesurfer was used to automatically segment the hippocampus and its subfields. We also examined associations between hippocampal subfields and tests of memory function. Both the AD and DLB groups demonstrated significant atrophy of the total hippocampus relative to HC but the DLB group was characterized by preservation of the cornu ammonis 1 (CA1), fimbria, and fissure. In contrast, all the hippocampal subfields except the fissure were significantly atrophied in AD compared with both DLB and HC groups. Among DLB subjects, CA1 was correlated with the Recent Memory score of the CAMCOG and Delayed Recall subscores of the HVLT. DLB is characterized by milder hippocampal atrophy that was accompanied by preserv...Continue Reading

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Citations

Jan 31, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Carmen Andreescu, Howard J Aizenstein
Jul 28, 2016·Brain : a Journal of Neurology·Lidia SarroKejal Kantarci
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Mar 6, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Elizabeth Frances McKiernan, John Tiernan O'Brien
Jul 12, 2017·Dementia and Geriatric Cognitive Disorders Extra·Yasuhiro NagahamaNorio Suzuki
Sep 25, 2020·Neurodegenerative Disease Management·Miguel Germán BordaKetil Oppedal
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Aug 4, 2020·Frontiers in Neuroscience·Lin HuangQihao Guo
Oct 27, 2018·Frontiers in Aging Neuroscience·Fenglian ZhengJianfeng Qiu
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Nov 17, 2020·Frontiers in Neurology·Mark R EthertonNatalia S Rost
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Mar 13, 2021·NeuroImage. Clinical·Julia SchumacherAlan J Thomas
Mar 26, 2021·The European Journal of Neuroscience·Isabella Hoi Kei LeungShantel Leigh Duffy

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