Differential attenuation of some effects of haloperidol in rats given scopolamine

European Journal of Pharmacology
P E SetlerG M McKenzie

Abstract

In a series of pharmacological tests the ability of 0.6 mg/kg of the anticholinergic scopolamine to decrease the effectiveness of the neuroleptic heloperidol varied widely. Most severely attenuated was production of catalepsy followed in order of decreasing interference by inhibition of amphetamine-induced rotation, inhibition of amphetamine- or apomorphine-induced stereotyped behavior, inhibition of conditioned avoidance responding and lastly attenuation of the haloperidol-induced increase in striatal HVA. By use of such a relatively low dose of scopolamine the behavioral effects of heloperidol were dissociated from effects on dopamine turnover in the striatum. If behavioral tests in animals can be related to the clinical effects of neuroleptic drugs, those effects of haloperidol severely reduced by scopolamine may be related to extrapyramidal effects.

References

Jun 1, 1975·The Journal of Pharmacy and Pharmacology·G BartholiniA Pletscher
Nov 7, 1975·Science·P M GrovesG V Rebec
Feb 1, 1972·British Journal of Pharmacology·M B Bowers, R H Roth
Dec 1, 1974·The Journal of Pharmacy and Pharmacology·P Muller, P Seeman
Jun 1, 1971·The Journal of Pharmacy and Pharmacology·N E Andén, P Bédard

Citations

Jan 1, 1980·Psychopharmacology·T C De Lima, J Palermo Neto
Nov 19, 1981·European Journal of Pharmacology·R D SturgeonH Y Meltzer
Jun 10, 1981·European Journal of Pharmacology·J T McDevitt, P E Setler
May 28, 1985·European Journal of Pharmacology·C ScavoneM L Aizenstein
May 10, 1988·European Journal of Pharmacology·Roberto Frussa-Filho, J Palermo-Neto
Aug 11, 1989·European Journal of Pharmacology·M R Sandoval, J Palermo-Neto
Jul 1, 1982·Neuropharmacology·A CampbellR J Baldessarini
Jan 1, 1987·Physiology & Behavior·L F FelicioJ Palermo-Neto
Oct 1, 1991·Physiology & Behavior·Roberto Frussa-Filho, J Palermo-Neto
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·D Wirtshafter, K E Asin
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·S Chiavegatto, M M Bernardi
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·M L AizensteinR DeLucia
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·A RobertsonC MacDonald
Jan 1, 1984·General Pharmacology·R DeLuciaM L Aizenstein
Jan 1, 1987·General Pharmacology·A Poli, J Palermo-Neto
Jan 1, 1990·General Pharmacology·J Palermo-Neto, V A Dorce
Jan 1, 1990·General Pharmacology·Jorge Camilo Flório, J Palermo-Neto
Oct 1, 1994·General Pharmacology·A R RigonR N Takahashi
Jan 1, 1980·Neuroscience·C J Pycock
Aug 1, 1992·Brain Research Bulletin·V A Dorce, J Palermo-Neto
Mar 1, 1990·Journal of Ethnopharmacology·S L GórniakH de Souza-Spinosa
Jan 1, 1995·Journal of Ethnopharmacology·M J BatatinhaM M Bernardi
Apr 23, 2003·Life Sciences·V C AbílioRoberto Frussa-Filho
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·E E HuckeL F Felicio
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·A C FerrazC Da Cunha
Apr 3, 1999·General Pharmacology·J Palermo-NetoM A B F Vital
Sep 24, 1999·Neurotoxicology and Teratology·A C MonizM M Bernardi
Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S R JocaR Andreatini
Mar 12, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J C PerryJ Palermo-Neto
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cibele Cristina ChinenRoberto Frussa-Filho
Aug 1, 1993·Pharmacology & Toxicology·Jorge Camilo FlórioJ Palermo-Neto
Jul 21, 1998·Annals of the New York Academy of Sciences·M B VitalJ Palermo-Neto
Apr 1, 1997·The Journal of Pharmacy and Pharmacology·Roberto Frussa-FilhoJ Palermo-Neto
Jun 22, 1999·Biological Psychiatry·V C AbílioRoberto Frussa-Filho
Sep 30, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Thaísa M SandiniH S Spinosa
Jul 29, 2010·The Journal of Pharmacy and Pharmacology·Eduardo L G MoreiraRosa Maria Ribeiro-do-Valle
Jun 9, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aline R BorçoiRoberto Frussa-Filho
Sep 3, 2013·Toxicon : Official Journal of the International Society on Toxinology·Luciana A CholichOfelia C Acosta
Jun 19, 2004·Neurotoxicology and Teratology·C A LazariniM M Bernardi
Jul 1, 2008·Neurotoxicology and Teratology·Plinio das N FavaroEstefânia Gastaldello Moreira
Jul 12, 2005·Neurotoxicology and Teratology·A C MonizM M Bernardi
Sep 6, 2005·Human & Experimental Toxicology·C Q MoreiraEstefânia Gastaldello Moreira
Feb 1, 1982·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·E Murzi, L J Herberg
Jun 20, 2019·Current Protocols in Neuroscience·Fausto Pierdoná GuzenDayane Pessoa de Araújo
Apr 10, 2021·Behavioural Brain Research·Camila RigobelloEstefânia Gastaldello Moreira

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