Differential back-invasion of a single complex dendrite of an abducens motoneuron by N-methyl-D-aspartate-induced oscillations: a simulation study

Neuroscience
S M KorogodS Tyc-Dumont

Abstract

Intracellular recording of abducens motoneurons in vivo has shown that ionophoretic applications of N-methyl-D-aspartate produced long-lasting membrane potential oscillations including a slow depolarization plateau with a burst of fast action potentials. This complex N-methyl-D-aspartate pattern was reproduced in the model of abducens motoneuron in vivo identified, intracellularly stained with horseradish peroxidase and reconstructed at high spatial resolution. The excitable soma of the simulated cell contained voltage-gated Ca, Na and K conductances, N-methyl-D-aspartate-gated voltage-sensitive Ca-Na-K conductance and Ca-dependent K conductance. The dendrite was passive either completely or with the exception of branching nodes containing N-methyl-D-aspartate conductances of the same slow kinetics but of lower values than at the soma. In the completely passive case, the N-methyl-D-aspartate pattern decayed with different rates along different dendritic paths depending on the geometry and topology of the reconstructed dendrite. The branches formed four clusters discriminated in somatofugal attenuations of steady voltages, and were correspondingly discriminated in attenuation of the complex N-methyl-D-aspartate pattern. Fast spi...Continue Reading

References

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Jul 1, 1991·The European Journal of Neuroscience·Jacques Durand

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Citations

Apr 25, 2000·Journal of Neuroscience Methods·G Horcholle-BossavitS Tyc-Dumont
Dec 21, 2002·The European Journal of Neuroscience·S M KorogodS Tyc-Dumont
Dec 3, 2008·The European Journal of Neuroscience·Dan Bar-YehudaAlon Korngreen
Nov 3, 2016·Journal of Neurophysiology·Mara Almog, Alon Korngreen
Dec 14, 1999·Learning & Memory·V Sourdet, D Debanne

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