Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex.

Journal of Molecular Neuroscience : MN
Jos PrickaertsRudy Schreiber

Abstract

Monoamine reuptake inhibitors increase brain-derived neurotrophic factor (BDNF) activity, and this growth factor is regarded as an interesting target for developing new antidepressant drugs. The aims of this study were to evaluate whether monoaminergic reuptake inhibition increases BDNF in vivo and in vitro as predicted by the neurotrophic hypothesis of depression, and whether triple reuptake inhibition has a superior BDNF response compared to dual reuptake inhibition. Twenty-one days of oral treatment (30 mg/kg) with the dual serotonin/noradrenaline reuptake inhibitor duloxetine or the triple serotonin/noradrenaline/dopamine reuptake inhibitor DOV 216,303 restored BDNF protein levels in the rat hippocampus, which were initially decreased due to injection stress. The prefrontal cortex contained increased BDNF levels only after DOV 216,303 treatment. In vitro, neither duloxetine nor DOV 216,303 altered intracellular BDNF levels in murine HT22 neuronal cells. In contrast, BDNF release was more effectively decreased following treatment with DOV 216,303 in these cells. In rat C62B astrocytomas, both antidepressants increased intracellular BDNF levels at their highest nontoxic concentration. C62B astrocytomas did not release BDNF, e...Continue Reading

References

Sep 1, 1997·Physiology & Behavior·J A Van der HeydenB Olivier
Jun 23, 2000·Biological Psychiatry·T M MadsenA Tingström
Jul 13, 2000·Molecular Psychiatry·B L JacobsF H Gage
Nov 7, 2000·Biological Psychiatry·R S DumanC D'Sa
Dec 1, 2001·Science·R LeeB L Hempstead
May 3, 2002·Nature·Hongjun SongFred H Gage
Nov 27, 2002·Psychiatry Research·Philip HeiserHelmut Vedder
Oct 3, 2003·Trends in Neurosciences·Bruce RansomMaiken Nedergaard
Oct 17, 2003·Life Sciences·Phil SkolnickArnold S Lippa
Oct 31, 2003·Trends in Neurosciences·Philip J Horner, Theo D Palmer
Oct 1, 2004·Journal of Molecular Neuroscience : MN·Gilles MercierMichel Pierre
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mikko SairanenEero Castrén
May 17, 2005·Brain Research. Molecular Brain Research·Félicien KaregeRomano La Harpe
Aug 3, 2005·Nature Reviews. Neuroscience·Bai LuNewton H Woo
Jul 11, 2006·Brain Research·Damijana Mojca JuricMarija Carman-Krzan
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Boldizsár CzéhEberhard Fuchs
Mar 1, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesca CalabreseMarco A Riva
Jun 15, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Chi-Hsien PengChun-Lan Kao
Sep 16, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M E BreuerB Olivier
Jul 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maura BoldriniVictoria Arango
Oct 6, 2010·Journal of Pharmacological Sciences·Saori ShimadaYoshihisa Ito

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Citations

Oct 17, 2015·Expert Review of Neurotherapeutics·Liang PengBaoman Li
May 29, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Amanda P Borrow, Nicole M Cameron
Nov 15, 2017·Neurochemical Research·Daiane Fátima EngelNelson Horácio Gabilan
Nov 23, 2017·Frontiers in Cellular Neuroscience·Yong XuRena Li
Nov 25, 2020·Journal of Molecular Neuroscience : MN·Tarapati RanaSimona Bungau

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Methods Mentioned

BETA
ELISA
protein assay
dissection

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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