PMID: 6168580Jan 1, 1981Paper

Differential behavior of cytotoxic effector cells against HLA antigens in strong genetic linkage disequilibrium

Immunogenetics
S J KimB Dupont

Abstract

Five sets of cytotoxic effector cells were generated, using haplo-identical, first degree relatives in five different families, against the HLA-A3; B7 serological determinants combined with different DR antigens. When tested against a panel of cells bearing combinations of the HLA-A, -B and -DR antigens it was shown that the HLA-B7 antigen was as strong a CML target determinant alone as it was in the presence of HLA-A3. The strength of the HLA-A3 antigen as target determinant varied. With effector cells primed to the HLA-A3; B7; DR2 haplotype, the A3 antigen alone behaved as a weak target determinant. When the same target cells were tested with the effector cells generated against HLA-A3; B7 without DR2, the A3 antigen behaved as a strong target determinant. A number of target cells lacking the serologically detectable HLA determinants present on the sensitizing HLA haplotype were identified as being killed by specific effector cells. These data suggest either a number of new CML target determinants controlled by different loci or the presence of a single, new locus with multiple alleles controlling CML targets.

References

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Nov 1, 1976·Tissue Antigens·T KristensenF Kissmeyer-Nielsen
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Feb 1, 1979·The Journal of Experimental Medicine·C Feighery, P Stastny
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Jul 5, 1972·Nature: New Biology·M O de Landazuri, R B Herberman

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Citations

Apr 1, 1984·Human Immunology·M H BreuningP Iványi

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