Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome

The New England Journal of Medicine
P J SchmidtD R Rubinow

Abstract

The symptoms of women with premenstrual syndrome improve in response to suppression of ovarian function, although these women have no evidence of ovarian dysfunction. We undertook a study to determine the role of estrogen and progesterone in this syndrome. We first studied the effect of ovarian suppression with leuprolide, an agonist analogue of gonadotropin-releasing hormone, or placebo on symptoms in 20 women with the premenstrual syndrome. Ten women whose symptoms improved during leuprolide treatment were given estradiol and progesterone in a double-blind, crossover design, each for four weeks, during continued leuprolide administration. Women without premenstrual syndrome (normal women) participated in a similar protocol. Outcomes were assessed on the basis of daily self-reports by the patients and biweekly rater-administered symptom-rating scales. The 10 women with premenstrual syndrome who were given leuprolide had a significant decrease in symptoms as compared with base-line values and with values for the 10 women who were given placebo. The 10 women with premenstrual syndrome who were given leuprolide plus estradiol or progesterone had a significant recurrence of symptoms, but no changes in mood occurred in 15 normal wo...Continue Reading

References

Apr 1, 1992·The American Journal of Psychiatry·S W HurtJ F Steege
Mar 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S Y HussainP M O'Brien
Apr 25, 1991·The New England Journal of Medicine·P J SchmidtD R Rubinow
Jan 1, 1988·Acta Obstetricia Et Gynecologica Scandinavica·S Hammarbäck, T Bäckström
Oct 1, 1986·American Journal of Obstetrics and Gynecology·R F Casper, A M Powell
Dec 1, 1986·Acta Psychiatrica Scandinavica·U HalbreichJ Nee
Nov 1, 1985·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·U HalbreichJ Lesser
May 1, 1971·The Journal of Clinical Endocrinology and Metabolism·G E AbrahamW D Odell
Nov 22, 1984·The New England Journal of Medicine·K N MuseS C Yen
Jun 1, 1983·Psychiatry Research·R F Haskett, J M Abplanalp
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH

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Citations

Mar 14, 2000·Hormones and Behavior·S Jacob, M K McClintock
Dec 20, 2005·Psychopharmacology·Anna-Carin N-WihlbäckTorbjörn Bäckström
May 26, 2006·Psychopharmacology·C Neill EppersonGraeme F Mason
Jul 2, 2008·Archives of Gynecology and Obstetrics·Miranda A FarageAllan B MacLean
Oct 6, 2005·Archives of Women's Mental Health·N Kurshan, C Neill Epperson
Dec 22, 2005·Archives of Women's Mental Health·A H ClaytonW Evans
Jan 13, 2011·Archives of Women's Mental Health·Patrick Michael Shaughn O'BrienKimberley Yonkers
Jan 8, 2013·Archives of Women's Mental Health·Susanne WinkelJulia Martini
Jan 9, 2013·Archives of Women's Mental Health·Melissa M ButtnerMichael W O'Hara
Apr 30, 2013·Archives of Women's Mental Health·Tracy NevatteUNKNOWN Consensus Group of the International Society for Premenstrual Disorders
Jul 22, 2004·Current Diabetes Reports·Kimberly K Trout, Karen L Teff
Nov 15, 2001·Current Psychiatry Reports·L Born, M Steiner
Nov 21, 2002·Current Psychiatry Reports·Uriel Halbreich
Mar 27, 2013·Paediatric Drugs·Andrea J Rapkin, Judith A Mikacich
Aug 28, 2013·Progress in Neurobiology·T BäckströmG van Wingen
Nov 5, 2013·Frontiers in Neuroendocrinology·Mary K Holder, Jeffrey D Blaustein
Nov 10, 1998·Biological Psychiatry·D R RubinowC A Roca
Nov 10, 1998·Biological Psychiatry·H Joffe, L S Cohen
Apr 10, 1999·Brain Research·M I Al-DahanR H Thalmann
May 24, 2003·Comprehensive Psychiatry·Miki BlochDavid R Rubinow
Dec 7, 2002·Obstetrics and Gynecology·Uriel HalbreichLee Cohen
Mar 21, 2003·Journal of Affective Disorders·Tracey J Shors, Benedetta Leuner
Mar 21, 2003·Journal of Affective Disorders·Meir SteinerLeslie Born
Oct 16, 2001·Biological Psychology·J A JenkinsF Petty
Jan 3, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R EcochardJ F Guerin
Oct 18, 2002·Psychoneuroendocrinology·P J SchmidtL St Clair
Aug 2, 2003·Psychoneuroendocrinology·Uriel Halbreich
Dec 8, 2004·Visual Neuroscience·Alvin EisnerMaureen D Toomey
Feb 12, 2005·Development and Psychopathology·Elaine F WalkerRebecca Huot
Jun 6, 2008·International Psychogeriatrics·Joanne RyanMarie-Laure Ancelin

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