Differential biocide susceptibility of the multiple genotypes of Mycobacterium immunogenum

Journal of Industrial Microbiology & Biotechnology
Suresh B SelvarajuJagjit S Yadav

Abstract

The non-tuberculous mycobacterium Mycobacterium immunogenum colonizes industrial metalworking fluids (MWFs) presumably due to its relative resistance to the currently practiced biocides and has been implicated in occupational respiratory hazards, particularly hypersensitivity pneumonitis. With an aim to understand its inherent biocide susceptibility profile and survival potential in MWF, five different genotypes of this organism, including a reference genotype (700506) and four novel test genotypes (MJY-3, MJY-4, MJY-10 and MJY-12) isolated in our recent study from diverse MWF operations were evaluated. For this, two commercial biocide formulations, Grotan (Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine) and Kathon (5-chloro-2-methyl-4-isothiazolin-3-one) currently practiced for the control of microorganisms, including mycobacteria, in MWF operations were tested. Effect of the fluid matrix on the biocide susceptibility was investigated for the synthetic (S) and semi-synthetic (SS) MWF matrices. In general, the minimum inhibitory concentration values were higher for the HCHO-releasing biocide Grotan than the isothiazolone biocide Kathon. All genotypes (except the reference genotype) showed lower susceptibility in SS as compared...Continue Reading

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Citations

Feb 10, 2009·Applied and Environmental Microbiology·Joseph O Falkinham
Nov 8, 2011·Applied and Environmental Microbiology·Jean-Benjamin MuratLaurence Millon
May 1, 2012·Applied Microbiology and Biotechnology·Ratul Saha, Robert S Donofrio
Oct 19, 2013·American Journal of Industrial Medicine·Coralie BarreraSandrine Roussel
Mar 26, 2013·International Journal of Occupational Medicine and Environmental Health·Elżbieta A Trafny
Oct 20, 2010·FEMS Microbiology Ecology·Sarah D Perkins, Largus T Angenent

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