Differential blockade of alpha-adrenoceptors by indoramin

British Journal of Clinical Pharmacology
D P NichollsR G Shanks


The effect of equihypotensive single oral doses of indoramin (mean dose 67 mg), phenoxybenzamine (mean dose 50 mg), hydralazine (mean dose 133 mg) and placebo on arterial pressure and heart rate in the supine and standing position was studied in six normal volunteers. Observations were made before and at 2 and 4 h after drug administration. Plasma noradrenaline (NA) was measured at each time interval in the supine position, and after 4 min of standing. Plasma renin activity (PRA) was measured at each time interval after 30 min in the standing position. The three active drugs reduced systolic arterial pressure in the standing position to a similar extent (indoramin, -24 mm Hg; phenoxybenzamine, -23.4 mm Hg; hydralazine, -30.4 mm Hg). The maximum effect of indoramin and phenoxybenzamine was observed at 4 h, and of hydralazine at 2 h after drug administration. The reductions of arterial pressure in the standing position were accompanied by increases in heart rate, plasma NA and PRA. Small increases were observed after indoramin (heart rate, + 9.2 beats min-1; plasma NA, + 126 pg/ml; PRA, + 0.33 ng angiotensin 1 ml-1 h-1), greater increases after phenoxybenzamine (heart rate, + 20; plasma NA, + 210; PRA, + 0.47), and the greatest i...Continue Reading


Jun 1, 1976·Circulation·W J MroczekF A FINNERTY
May 1, 1977·British Journal of Pharmacology·J C DoxeyJ M Walker
Jul 1, 1978·European Journal of Pharmacology·D C U'PrichardS H Snyder
Aug 1, 1978·The Journal of Pharmacy and Pharmacology·K F Rhodes, J F Waterfall
Oct 1, 1978·The Journal of Pharmacy and Pharmacology·D R Algate, J F Waterfall
May 1, 1975·European Journal of Pharmacology·T Baum, A T Shropshire
Nov 1, 1976·European Journal of Pharmacology·M F Lokhandwala, J P Buckley
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·A G RoachI Cavero
Jul 1, 1979·British Journal of Clinical Pharmacology·I B DaviesT Rosenthal
Oct 1, 1979·British Journal of Clinical Pharmacology·N Saar, R D Gordon
May 1, 1978·Annals of Internal Medicine·I J KOPINM G Ziegler
Aug 5, 1976·The New England Journal of Medicine·J Koch-Weser
Oct 1, 1975·Clinical Science and Molecular Medicine·C J MathiasW S Peart
Sep 1, 1969·The Journal of Clinical Endocrinology and Metabolism·N WinerA D Freedman
Aug 1, 1971·Journal of Applied Physiology·T A KotchenJ W Mason
Apr 1, 1967·The Journal of Clinical Investigation·R D GordonD P Island
Apr 1, 1980·The Journal of Pharmacy and Pharmacology·S KalsnerR E Dobson
Apr 1, 1981·The Journal of Pharmacy and Pharmacology·D R AlgateJ F Waterfall
Nov 1, 1980·Journal of Cardiovascular Pharmacology·G M Drew
Jun 19, 1980·The New England Journal of Medicine·B B Hoffman, R J Lefkowitz
Nov 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·J W Constantine, W Lebel
Feb 1, 1981·Clinical Pharmacology and Therapeutics·G A FitzGeraldC T Dollery
Jan 1, 1983·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Jan 1, 1982·European Journal of Clinical Pharmacology·M B MurphyC T Dollery
Jun 1, 1980·British Journal of Clinical Pharmacology·A J Man in 't VeldM A Schalekamp
Jun 21, 1954·Acta Physiologica Scandinavica·U VON EULERJ HELLSTROM
Jan 1, 1965·Journal of Neurochemistry·J GLOWINSKIJ AXELROD
Oct 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·E D FREIS, F A FINNERTY


Feb 1, 1987·Journal of the American College of Cardiology·C V LeierD V Unverferth
Aug 7, 1998·Journal of Psychopharmacology·C B Kelly, S J Cooper
Aug 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·C B Kelly, S J Cooper
Apr 1, 1988·British Journal of Clinical Pharmacology·A H DeeringR G Shanks
Aug 1, 1984·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Feb 1, 1985·British Journal of Clinical Pharmacology·D W HarronR G Shanks

Related Concepts

Adrenergic alpha-Antagonists
Pulse Rate
Norepinephrine, (+, -)-Isomer
Phenoxybenzamine Hydrochloride

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