Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics

The Journal of Pain : Official Journal of the American Pain Society
Qingmin ChenFrank Porreca

Abstract

Systemic administration of local anesthetics has been shown to transiently reverse thermal and tactile hypersensitivity induced by peripheral nerve injury, effects that have been taken as suggesting direct actions on the peripheral nerves. The present study sought to determine whether a central site of action could contribute to, or account for, the effects of lidocaine on nerve injury-induced thermal and tactile hypersensitivity. Systemic lidocaine and its peripherally restricted analogues, QX-314 or QX-222, effectively reversed thermal hypersensitivity after spinal nerve ligation injury. Nerve injury-induced tactile hypersensitivity, however, was reversed by systemic lidocaine but not QX-314 or QX-222. Microinjection of either lidocaine or QX-314 into the rostral ventromedial medulla fully reversed spinal nerve ligation-induced thermal and tactile hypersensitivity. The data strongly suggest that nerve injury-induced thermal and tactile hypersensitivity are mediated through different mechanisms. In addition, the present study supports a prominent contribution of the central nervous system in the activity of systemically given lidocaine against nerve injury-induced tactile and thermal hypersensitivity. Thus, lidocaine might rev...Continue Reading

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Citations

Mar 17, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Robert J SchwartzmanGuillermo M Alexander
May 16, 2009·European Journal of Pain : EJP·Raul SanojaFernando Cervero
Nov 25, 2006·Seminars in Cell & Developmental Biology·Marc RogersEdward B Stevens
Apr 25, 2006·The Journal of Pain : Official Journal of the American Pain Society·Ron AmirGary R Strichartz
Jan 24, 2006·The Journal of Pain : Official Journal of the American Pain Society·Nadine Attal, Didier Bouhassira
Jan 18, 2011·Brain Research·Amteshwar Singh Jaggi, Nirmal Singh
Aug 10, 2018·Scientific Reports·Mohammed Zacky AriffinSanjay Khanna
Dec 22, 2009·Journal of Medicinal Chemistry·Paul C FritchAlan D Wickenden

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