Differential blood-based diagnosis between benign prostatic hyperplasia and prostate cancer: miRNA as source for biomarkers independent of PSA level, Gleason score, or TNM status

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Petra LeidingerEckart Meese

Abstract

Since the benefit of prostate-specific antigen (PSA) screening remains controversial, new non-invasive biomarkers for prostate carcinoma (PCa) are still required. There is evidence that microRNAs (miRNAs) in whole peripheral blood can separate patients with localized prostate cancer from healthy individuals. However, the potential of blood-based miRNAs for the differential diagnosis of PCa and benign prostatic hyperplasia (BPH) has not been tested. We compared the miRNome from blood of PCa and BPH patients and further investigated the influence of the tumor volume, tumor-node-metastasis (TNM) classification, Gleason score, pretreatment risk status, and the pretreatment PSA value on the miRNA pattern. By microarray approach, we identified seven miRNAs that were significantly deregulated in PCa patients compared to BPH patients. Using quantitative real time PCR (qRT-PCR), we confirmed downregulation of hsa-miR-221* (now hsa-miR-221-5p) and hsa-miR-708* (now hsa-miR-708-3p) in PCa compared to BPH. Clinical parameters like PSA level, Gleason score, or TNM status seem to have only limited impact on the overall abundance of miRNAs in patients' blood, suggesting a no influence of these factors on the expression of deregulated miRNAs.

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Citations

Nov 3, 2016·Nature Reviews. Urology·Annika FendlerKlaus Jung
May 1, 2019·RNA Biology·Nicole LudwigChristina Backes
Jul 18, 2019·Journal for Immunotherapy of Cancer·Martin HartEckart Meese
Apr 19, 2017·Oncotarget·James R W McMullenMaheswari Senthil
Oct 6, 2017·Oncotarget·Rita DemidenkoSonata Jarmalaite
Apr 5, 2019·International Neurourology Journal·Jin Wook Kim
Jul 17, 2020·Cancer Management and Research·Christopher J McNallyDeclan J McKenna
Jan 10, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Kexiang ZhuFanghong Wang
Aug 17, 2019·Cellular Signalling·Si-Nan SunTao Xu
Mar 8, 2021·Experimental Gerontology·Franco F Roldán Gallardo, Amado A Quintar
May 1, 2021·Journal of Personalized Medicine·Katalin BalázsKatalin Lumniczky

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