Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506

Neuroscience
Cassia R OverkEliezer Masliah

Abstract

Abnormal accumulation of amyloid β (Aβ), α-synuclein (α-syn), and microtubule-associated protein tau (tau) have been implicated in neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and Pick's disease (PiD). The mechanisms through which aggregated versions of α-syn, Aβ, and tau may lead to neurodegeneration are not entirely clear, however, there is emerging evidence that neuronal calcium dysregulation is at play. Two-photon microscopy is a powerful tool that can be used to measure in vivo alterations of calcium transients using animal models of neurodegeneration, and when coupled with statistical methods to characterize functional signals, can reveal features that identify and discern between distinct mouse types. We studied four mouse models of neurodegenerative diseases, wild-type (WT) α-syn, E57K α-syn, amyloid precursor protein (APP), and triple-repeat (3R)-Tau and Non-transgenic (tg) littermates using two-photon microscopy. We found that for calcium transients, simple measures such as area under the curve (AUC) and peak width in the 1-Hz whisker pad stimulation paradigm, were significantly increased for WT α-syn, E57K α-syn and APP mice across all cortical depths compared to Non-tg mic...Continue Reading

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Citations

Aug 25, 2016·Biochemical and Biophysical Research Communications·Hilaree N FrazierOlivier Thibault
May 26, 2016·Journal of Neuroinflammation·Jerel A FieldsEliezer Masliah
Jan 29, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Cassia Overk, Eliezer Masliah
May 3, 2018·Acta Neuropathologica Communications·Jessica M FroulaLaura A Volpicelli-Daley
Jan 7, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN Alzheimer's Association Calcium Hypothesis Workgroup
Feb 28, 2019·Frontiers in Neuroscience·Marco Tulio Núñez, Cecilia Hidalgo
Mar 22, 2018·Science Signaling·Nancy R StallingsJames S Malter
Nov 10, 2020·Journal of Alzheimer's Disease : JAD·Adam O GhoweriOlivier Thibault

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