Differential Cardiac MicroRNA Expression Predicts the Clinical Course in Human Enterovirus Cardiomyopathy

Circulation. Heart Failure
Uwe KuehlWolfgang Poller

Abstract

Investigation of disease pathogenesis confined to protein-coding regions of the genome may be incomplete because many noncoding variants are associated with disease. We aimed to identify novel predictive markers for the course of enterovirus (CVB3) cardiomyopathy by screening for noncoding elements influencing the grossly different antiviral capacity of individual patients. Transcriptome mapping of CVB3 cardiomyopathy patients revealed distinctive cardiac microRNA (miR) patterns associated with spontaneous virus clearance and recovery (CVB3-ELIM) versus virus persistence and progressive clinical deterioration (CVB3-PERS). Profiling of protein-coding genes and 754 miRs in endomyocardial biopsies of test cohorts was performed at their initial presentation, and those spontaneously eliminating the virus were compared with those with virus persistence on follow-up. miR profiling revealed highly significant differences in cardiac levels of 16 miRs, but not of protein-coding genes. Evaluation of this primary distinctive miR pattern in validation cohorts, and multivariate receiver operating characteristic curve analysis, confirmed this pattern as highly predictive for disease course (area under the curve, 0.897±0.071; 95% confidence in...Continue Reading

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Aug 1, 2016·Genomics, Proteomics & Bioinformatics·Christine S SiegismundDirk Lassner
Sep 30, 2016·Molecular Diagnosis & Therapy·Eeva Auvinen
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Apr 4, 2021·International Journal of Molecular Sciences·Peiyu ZhuYuefei Jin
Oct 6, 2021·Cardiovascular Research·Heinz-Peter SchultheissFelicitas Escher

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