Differential CCR5Delta32 allelic frequencies in juvenile idiopathic arthritis subtypes: evidence for different regulatory roles of CCR5 in rheumatological diseases

Scandinavian Journal of Rheumatology
I ScheibelJ A B Chies

Abstract

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood and is characterized by persistent arthritis for at least 6 weeks. Its aetiopathogenesis is unknown but there is strong evidence that there is a substantial genetic component. Chemokine receptors genes are among the candidate genes for association with arthritis and other inflammatory diseases. The CC chemokine receptor 5 (CCR5)Delta32 polymorphism has been associated with rheumatoid arthritis (RA), conferring a protective effect. To determine whether the CCR5Delta32 polymorphism is associated with JIA and RA in Brazilian patients. We investigated 203 RA patients, 101 JIA patients, and 104 healthy individuals by amplification of the CCR5Delta32 deletion. We compared the allelic frequencies among these groups, as well as among different JIA subtypes. The frequency of the Delta32 allele was higher in JIA patients (9.4%) as compared to control subjects (3.8%) and RA patients (3.2%). Grouping the patients according to JIA subtypes, we observed a higher CCR5Delta32 allelic frequency in the subtypes with a greater inflammatory component: 4.1% in oligoarticular (n = 49), 11.2% in polyarticular (n = 40) [9.5% in rheumatoid factor negative (RF-...Continue Reading

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Citations

Jul 23, 2008·Pediatric Rheumatology Online Journal·Sampath Prahalad, David N Glass
May 14, 2010·Genes and Immunity·A HinksW Thomson
Sep 3, 2010·The American Journal of the Medical Sciences·Hervé C GérardAlan P Hudson
Jun 15, 2015·Rheumatology International·Thiago Hissnauer Leal BaltusEdna Maria Vissoci Reiche
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May 22, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Wlisses Henrique Veloso Silva-CarvalhoRafael Lima Guimarães
Jul 29, 2010·Zeitschrift für Rheumatologie·J P Haas
Aug 22, 2015·Nature Communications·Masao NagasakiMasayuki Yamamoto
Dec 4, 2013·Critical Reviews in Clinical Laboratory Sciences·Chloe Miu MakChing-Wan Lam
Sep 27, 2013·Journal of Human Genetics·Daisuke FujisawaFumio Endo
Jan 30, 2009·Scandinavian Journal of Rheumatology·G Pont-KingdonS Prahalad
Oct 9, 2009·Autoimmunity·H A MartensM Bijl
Nov 6, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Aline R MatosMarilda M Siqueira

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