Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measured with EEG and fMRI

Frontiers in Human Neuroscience
Till NierhausClaudia M Witt

Abstract

Acupuncture can be regarded as a complex somatosensory stimulation. Here, we evaluate whether the point locations chosen for a somatosensory stimulation with acupuncture needles differently change the brain activity in healthy volunteers. We used EEG, event-related fMRI, and resting-state functional connectivity fMRI to assess neural responses to standardized needle stimulation of the acupuncture point ST36 (lower leg) and two control point locations (CP1 same dermatome, CP2 different dermatome). Cerebral responses were expected to differ for stimulation in two different dermatomes (CP2 different from ST36 and CP1), or stimulation at the acupuncture point vs. the control points. For EEG, mu rhythm power increased for ST36 compared to CP1 or CP2, but not when comparing the two control points. The fMRI analysis found more pronounced insula and S2 (secondary somatosensory cortex) activation, as well as precuneus deactivation during ST36 stimulation. The S2 seed-based functional connectivity analysis revealed increased connectivity to right precuneus for both comparisons, ST36 vs. CP1 and ST36 vs. CP2, however in different regions. Our results suggest that stimulation at acupuncture points may modulate somatosensory and saliency pr...Continue Reading

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Citations

Nov 3, 2016·Frontiers in Human Neuroscience·Xiangyu LongDaniel Pach
Aug 30, 2018·Chinese Journal of Integrative Medicine·Chao-Chao YuMiao Wu
Oct 16, 2015·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Weidong GuZhaoxin Wang
Sep 24, 2019·Frontiers in Integrative Neuroscience·Xiangyu Guo, Tao Ma
Mar 28, 2019·Frontiers in Neuroscience·Till NierhausDaniel Pach
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yarui WeiBensheng Qiu
Sep 16, 2019·The Journal of Pain : Official Journal of the American Pain Society·Nuno M P de MatosClaudia M Witt
Apr 17, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaoling LiFeng Wang

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Software Mentioned

SPM
Matlab
AlphaSim
MASS
AFNI
CompCor
DPABI
REST

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