Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington's Disease and Parkinson's Disease Human Brains

Journal of Neurodegenerative Diseases
C FourieJ M Montgomery

Abstract

NMDA and AMPA-type glutamate receptors and their bound membrane-associated guanylate kinases (MAGUKs) are critical for synapse development and plasticity. We hypothesised that these proteins may play a role in the changes in synapse function that occur in Huntington's disease (HD) and Parkinson's disease (PD). We performed immunohistochemical analysis of human postmortem brain tissue to examine changes in the expression of SAP97, PSD-95, GluA2 and GluN1 in human control, and HD- and PD-affected hippocampus and striatum. Significant increases in SAP97 and PSD-95 were observed in the HD and PD hippocampus, and PSD95 was downregulated in HD striatum. We observed a significant increase in GluN1 in the HD hippocampus and a decrease in GluA2 in HD and PD striatum. Parallel immunohistochemistry experiments in the YAC128 mouse model of HD showed no change in the expression levels of these synaptic proteins. Our human data show that major but different changes occur in glutamatergic proteins in HD versus PD human brains. Moreover, the changes in human HD brains differ from those occurring in the YAC128 HD mouse model, suggesting that unique changes occur at a subcellular level in the HD human hippocampus.

References

Nov 1, 1992·Journal of Clinical and Experimental Neuropsychology·R DiamondJ Vasterling
Jan 1, 1991·European Neurology·W R Gibb
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·J P VonsattelE P Richardson
Jul 29, 1998·Brain : a Journal of Neurology·A D LawrenceB J Sahakian
Feb 5, 1999·Progress in Brain Research·R J Wenthold, K W Roche
Apr 10, 1999·Human Molecular Genetics·M T UsdinD V Madison
May 21, 1999·The European Journal of Neuroscience·P BassandM Khrestchatisky
Dec 18, 2001·Journal of Neuroscience Research·C CepedaM S Levine
Oct 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Eric SchnellRoger A Nicoll
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Dec 10, 2003·Brain : a Journal of Neurology·Bryan R JarabekBarry B Wolfe
Apr 20, 2004·Cellular and Molecular Life Sciences : CMLS·J M MontgomeryC C Garner
Feb 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J E NashJ M Brotchie
Apr 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy M Van RaamsdonkMichael R Hayden
May 10, 2005·Journal of Neuroscience Research·Marjorie A ArianoAnne E Grissell
Nov 10, 2005·Human Molecular Genetics·Jeremy M Van RaamsdonkMichael R Hayden
Mar 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fabrizio GardoniPaolo Calabresi
Dec 26, 2006·Progress in Neurobiology·Mannie M Y Fan, Lynn A Raymond
Mar 14, 2007·Parkinsonism & Related Disorders·Tjalf Ziemssen, Heinz Reichmann
Apr 5, 2007·Nature Protocols·Henry J WaldvogelRichard L M Faull
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mannie M Y FanLynn A Raymond
Apr 21, 2007·The Journal of Comparative Neurology·Henry J WaldvogelRichard L M Faull
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hong CuiMichael Tymianski
Dec 22, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·J S PaulsenUNKNOWN Predict-HD Investigators and Coordinators of the Huntington Study Group
Feb 19, 2008·Cellular and Molecular Life Sciences : CMLS·K L DoubleU T Brunk
Sep 11, 2008·Journal of Alzheimer's Disease : JAD·Geneviève LeubaBéat Michel Riederer
Feb 10, 2009·Biological Psychiatry·Sven SchipplingMichael Orth
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clarissa L WaitesCraig C Garner
Jul 22, 2009·Nature Neuroscience·Okunola JeyifousWilliam N Green
Aug 26, 2009·CNS & Neurological Disorders Drug Targets·Kari A JohnsonColleen M Niswender

❮ Previous
Next ❯

Citations

Oct 29, 2017·Scientific Reports·Marie K BondulichGillian P Bates
Jun 4, 2020·The European Journal of Neuroscience·Olimpia E CurranSeth G N Grant
Nov 15, 2017·Acta Neuropathologica·Isabelle St-AmourSébastien S Hébert
Aug 1, 2020·Cell Death & Disease·Núria Martín-FloresCristina Malagelada
Feb 7, 2021·Acta Neuropathologica·Jordi Creus-MuncunillEulàlia Martí
Dec 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gonçalo P RosaMaria Carmo Barreto

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR
electrophoresis

Software Mentioned

SPSS
Image J
Gel Analyser

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

© 2021 Meta ULC. All rights reserved