PMID: 9663605Jul 15, 1998Paper

Differential characteristics of two new tumorigenic cell lines of human breast carcinoma origin

International Journal of Cancer. Journal International Du Cancer
V J MöbusR Kreienberg

Abstract

Permanent human tumor cell lines are an important tool for the study of breast cancer. Two new breast cancer cell lines (BrCa-MZ-01 and BrCa-MZ-02) were isolated from a solid tumor and a pleural effusion, respectively. One cell line was established from a medullary carcinoma, the other from a ductal carcinoma. These cells exhibit ultrastructural and immunohistochemical features of epithelial cells of mammary origin. Intermediate filament and cytokeratin typing showed a clear predominance of the simple-epithelial cytokeratins CK 8, CK 18 and CK 19, although the expression was reduced in comparison to the hormone receptor-positive reference cell lines MCF-7 and ZR-75-1. Both cell lines produced slow-growing tumors after subcutaneous (s.c.) transplantation of 1 x 10(7) viable tumor cells into nude mice. The cell line BrCa-MZ-01 expresses the estrogen and progesterone receptor, whereas the cell line BrCa-MZ-02 remains negative. Both cell lines are positive for secretion of platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta), whereas interleukin-6 (IL-6) is only secreted by the cell line BrCa-MZ-02.

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Citations

Apr 20, 2004·Journal of Cellular Physiology·Stella Maris VázquezIsabel Alicia Lüthy
Sep 28, 2002·Genes, Chromosomes & Cancer·Cornel PopoviciMax Chaffanet
Oct 9, 2002·The American Journal of Pathology·Christophe GinestierJocelyne Jacquemier
Oct 20, 2006·Journal of Molecular Biology·Axel VicartBrigitte Kahn-Perlès
Aug 12, 2010·Molecular Cancer·Lynda Addou-KloucheMax Chaffanet
Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·T YokoeY Morishita
Jan 12, 2011·Cell Biochemistry and Biophysics·Junchuan LiLanying Zou
Mar 10, 2004·Physiological Measurement·Jacques Jossinet, Anne Desseux
Feb 6, 2004·Breast Cancer Research and Treatment·Marc Lacroix, Guy Leclercq
Dec 29, 2005·Molecular Cancer Research : MCR·Véronique Gelsi-BoyerMax Chaffanet
Dec 12, 2001·Biochemical and Biophysical Research Communications·M OtsukaN Seki

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