PMID: 9553872Apr 29, 1998Paper

Differential chemotactic effect of cementum attachment protein on periodontal cells

Journal of Periodontal Research
Z MetzgerS Pitaru

Abstract

Selective re-population of the root surface by periodontal ligament cells is considered a key factor in periodontal regeneration. A recently isolated cementum attachment protein (CAP) has been shown to enhance fibroblast attachment. In the present study the potential of CAP to selectively attract periodontal ligament cells (PLC) was studied in vitro in a micro-chemotaxis system. Human periodontal ligament cells and gingival fibroblasts (GF) were compared for their chemotactic response to either cementum attachment protein or to fibronectin. Murine dermal fibroblasts (MDF) served as control, irrelevant to the periodontium. The chemotactic response of PLC to fibronectin at 10(-8) M was of a similar magnitude as that of GF (16 +/- 5 and 11 +/- 3 cells/field, respectively), but both were significantly lower than the response of MDF (28 +/- 3 cells/field). The chemotactic response of periodontal ligament cells to the cementum attachment protein at 10(-7) M was higher (36 +/- 5 cells/field) than that of gingival fibroblasts or murine dermal fibroblasts (14 +/- 2 and 16 +/- 2 cells/field, respectively). These results suggest that cementum attachment protein can influence the selective re-population of root surfaces by periodontal liga...Continue Reading

References

May 1, 1976·Journal of Periodontology·A H Melcher
Aug 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H ArzateA S Narayanan
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·I AukhilW Fernyhough
Mar 1, 1990·Journal of Periodontal Research·B McAllisterR C Page
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Citations

May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D Pavlin, J Gluhak-Heinrich
Jun 29, 1999·Journal of Periodontal Research·S IvanovskiA S Narayanan
May 12, 2006·Periodontology 2000·Margarita Zeichner-David
Dec 4, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Margarita Zeichner-DavidPablo Bringas
Dec 17, 2014·Periodontology 2000·Higinio ArzateGabriela Mercado-Celis

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