Differential cholinergic modulation of Ca2+ transients evoked by backpropagating action potentials in apical and basal dendrites of cortical pyramidal neurons

Journal of Neurophysiology
Kwang-Hyun ChoDuck-Joo Rhie

Abstract

The effect of the cholinergic agonist carbachol (CCh) on backpropagating action potential (bAP)-evoked Ca2+ transients in distal apical and basal dendrites of layer 2/3 pyramidal neurons in the primary visual cortex of rats was studied using whole cell recordings and confocal Ca2+ imaging. In the presence of CCh (20 microM), initial bAP-evoked Ca2+ transients were followed by large propagating secondary Ca2+ transients that were restricted to proximal apical dendrites < or =40 microm from the soma. In middle apical dendrites (41-100 microm from the soma), Ca2+ transients evoked by AP bursts at 20 Hz, but not by single APs, were increased by CCh without secondary transients. CCh failed to increase the bAP-evoked Ca2+ transients in distal apical dendrites (101-270 microm from the soma). In contrast, in basal dendrites, CCh increased Ca2+ transients evoked by AP bursts, but not by single APs, and these transients were relatively constant over the entire length of the dendrites. CCh further increased the enhanced bAP-evoked Ca2+ transients in the presence of 4-aminopyridine (200 microM), an A-type K+ channel blocker, in basal and apical dendrites, except in distal apical dendrites. CCh increased large Ca2+ transients evoked by high...Continue Reading

References

May 16, 2000·The Journal of Physiology·L D Pozzo-MillerS B Andrews
Jan 6, 2001·Science·M HäusserG J Stuart
Feb 13, 2001·Journal of Neurophysiology·P VetterM Häusser
Sep 29, 2001·Trends in Neurosciences·M P Blaustein, V A Golovina
Apr 3, 2003·Neuron·Panayiota PoiraziBartlett W Mel
Apr 15, 2003·The Journal of Physiology·Matthew E LarkumWilliam N Ross
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tycho M Hoogland, Peter Saggau
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tom BinzeggerKevan A C Martin
Oct 9, 2004·Progress in Biophysics and Molecular Biology·Jack WatersBert Sakmann
Mar 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon N JacobBarbara E Ehrlich
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yu-Dong ZhouJohn A White
Jul 14, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Björn M Kampa, Greg J Stuart
Oct 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johannes J LetzkusGreg J Stuart
Nov 24, 2006·Journal of Neurophysiology·Allan T GulledgeGreg J Stuart
Aug 24, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew Evan LarkumFritjof Helmchen

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Citations

Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Allan T GulledgeHermes H Yeh
Jun 18, 2010·Journal of Neurophysiology·Kwang-Hyun ChoDuck-Joo Rhie
Oct 21, 2011·Journal of Neurophysiology·Hyun-Jong JangDuck-Joo Rhie
Mar 22, 2014·The European Journal of Neuroscience·Omari S KhalilTrevor W Stone
Nov 28, 2019·Nature Communications·Jiyoung ParkStelios M Smirnakis

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