PMID: 9541576Apr 29, 1998Paper

Differential chronology of TCRADV2 gene use by alpha and delta chains of the mouse TCR

European Journal of Immunology
Evelyne Jouvin-MarcheP N Marche

Abstract

The genes coding for TCR alpha and delta chains share the same genetic locus (TCRA/D). The rules governing the utilization of a V gene with the alpha and delta chains have not been established. More specifically, it is not known whether the position of a gene within the locus influences its utilization in alpha and delta TCR. To elucidate these points, we mapped ADV2 genes in the TCRA/D locus of BALB/c mice and analyzed their utilization in TCR alpha and delta transcripts from thymi isolated from mice of different ages. Our results show that all ADV2 genes can be used by the two chains, but with strikingly different patterns. Moreover, ADV2 utilization by the alpha chain proceeds in successive concentric waves during development, suggesting a progressive regulation of gene accessibility and utilization. These results support independent control of TCRA and TCRD gene assembly.

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Citations

Dec 8, 1998·European Journal of Immunology·M GallagherE Jouvin-Marche
Feb 23, 2010·PLoS Computational Biology·Florence ThuderozEvelyne Jouvin-Marche
May 27, 2008·Molecular Immunology·Cédric TouvreySerge M Candéias
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M GallagherE Jouvin-Marche
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Huang, O Kanagawa
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S J ManciniE Jouvin-Marche

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