Differential Claudin 3 and EGFR Expression Predicts BRCA1 Mutation in Triple-Negative Breast Cancer

Cancer Investigation
Sabine DanzingerkConFab Investigators

Abstract

BRCA-1 mutation-associated triple-negative breast cancer (TNBC) has been hypothesized to exhibit a phenotype that is distinct from non-mutation carriers. We have analyzed immunohistochemically detected cytokeratins 5 and 14, epidermal growth factor receptor (EGFR), claudin (CLDN) 3, 4, and 7, and E-cadherin in 57 TNBC (32 BRCA1 and 8 BRCA2 tumors, 17 WT tumors). Positive staining of CLDN3 and negative EGFR expression in TNBC are associated with a BRCA1 mutation. EGFR and CLDN3 expression was able to predict the presence of BRCA1 mutation (area under curve 0.802, p < 0.001). This could help in guiding the decision for BRCA testing.

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Citations

Dec 22, 2019·International Journal of Molecular Sciences·Saiprasad GowrikumarPunita Dhawan
Jan 16, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Meiling HuangNanlin Li
Nov 2, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Oliver TruslerAndrew L Laslett

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