Differential contribution of cholecystokinin receptors to stress-induced modulation of seizure and nociception thresholds in mice

Pharmacology, Biochemistry, and Behavior
Houman Homayoun, Ahmad Reza Dehpour

Abstract

Recent evidence suggest that endogenous cholecystokinin (CCK) has important roles in central responses to stress. CCK receptors are known as functional modulators of opioidergic system with a tonic antiopioid effect in nociceptive pathways. In contrast, CCK receptor ligands are known to induce anticonvulsant effects similar to endogenous opioids. It is not clear whether endogenous CCK may play a role in the anticonvulsant effects of stress, especially in those stressful paradigms that are associated with strong activation of opioid pathways. The present study examined the role of endogenous CCK receptors in acute stress-induced modulation of seizure (clonic seizures induced by pentylenetetrazole) and nociception (tail-flick) thresholds. Acute restraint stress (for 2 h) and prolonged intermittent footshock stress (30 min) both induced opioid-dependent anticonvulsant and antinociceptive effects. While CCK receptor antagonist proglumide (10, 20, or 40 mg/kg) had no effect on seizure or nociception threshold by itself, it inhibited the anticonvulsant effects of both these types of stress while potentiating their antinociceptive effects. Moreover, proglumide exerted a similar inhibition of the anticonvulsant effect and potentiation ...Continue Reading

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Mar 2, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hossein RastegarAhmad Reza Dehpour

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Citations

Jan 25, 2008·Journal of Neural Transmission·Danka PericićDubravka Svob Strac
May 4, 2006·Nutritional Neuroscience·S YehudaD I Mostofsky
Sep 17, 2010·Anesthesia Progress·K C BarcelosD A Haas
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
May 1, 2021·International Journal of Molecular Sciences·Claudia Espinosa-GarciaAsheebo Rojas

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