Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists

The Journal of Allergy and Clinical Immunology
Elena GolevaDonald Y m Leung

Abstract

Combination treatment with steroids and long-acting beta2-agonists provides greater asthma control than simply increasing the dose of steroids. Although the effects of combination treatment with steroids and long-acting beta2-agonists have been attributed to their anti-inflammatory and bronchodilator effects, the ability of this combination to act synergistically on T cells has not been explored. PBMCs from control subjects and allergic asthmatic patients were stimulated with PHA in the presence of low doses of fluticasone propionate (FP) with or without salmeterol for 72 hours. The inhibition of T-cell proliferation, cytokine production, and glucocorticoid receptor translocation was measured. Both groups showed a similar degree of inhibition of PHA-induced T-cell proliferation with FP (inhibitory concentration of 50% approximately 10(-9) mol/L) alone. Use of lower concentrations of FP (10(-12) to 10(-11) mol/L) in combination with salmeterol (10(-10) to 10(-7) mol/L) in control subjects provided similar inhibition of proliferation. This combination treatment was associated with significantly greater glucocorticoid receptor translocation into the cell nucleus compared with that seen with FP alone (10(-12) mol/L; P <.01). In con...Continue Reading

References

Jan 1, 1990·European Journal of Clinical Pharmacology·W KrauseN Sauerbrey
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·M I AnsteadN K Burki
Apr 29, 1998·Chest·R H MooreB F Dickey
Jul 22, 1998·Respiration; International Review of Thoracic Diseases·S OdderaG A Rossi
Jul 27, 1999·The Journal of Investigative Dermatology·L F SantamariaJ Beleta
Dec 23, 1999·Current Opinion in Pulmonary Medicine·D A HandleyM E Snider
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·A KanehiroE W Gelfand
Dec 12, 2001·Journal of Molecular and Cellular Cardiology·S MoniotteJ L Balligand
Dec 12, 2001·British Journal of Clinical Pharmacology·L ThorssonC G Löfdahl
May 10, 2002·The Journal of Biological Chemistry·Zhen WangMichael J Garabedian
May 16, 2002·Molecular Immunology·S Romagnani
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Richard J MartinChristine A Sorkness

❮ Previous
Next ❯

Citations

Jun 1, 2005·Pharmacology & Therapeutics·María Jesús SanzEsteban J Morcillo
Aug 9, 2007·International Archives of Allergy and Immunology·Tomomi HashimotoAkio Mori
Apr 23, 2005·American Journal of Respiratory Cell and Molecular Biology·Emma J PeekCatherine M Hawrylowicz
Mar 5, 2008·Journal of Occupational Medicine and Toxicology·Gaetano CaramoriAlberto Papi
Jun 3, 2010·Frontiers in Bioscience (Scholar Edition)·Matthew J Loza, Raymond B Penn
Feb 4, 2014·Seminars in Immunology·Caroline J Padro, Virginia M Sanders
Dec 2, 2005·International Reviews of Immunology·Johan VerhagenCezmi A Akdis
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Jason H C FriesenWilliam J Calhoun
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Mübeccel AkdisCezmi A Akdis
Mar 1, 2012·Preventive Nutrition and Food Science·Ji Ye MokSeon Il Jang
Nov 30, 2006·Current Opinion in Pulmonary Medicine·Richard M Effros, Hari Nagaraj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.