Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system

Proceedings of the National Academy of Sciences of the United States of America
Ieva GailiteNicolas Tapon

Abstract

The Hippo (Hpo) pathway is a highly conserved tumor suppressor network that restricts developmental tissue growth and regulates stem cell proliferation and differentiation. At the heart of the Hpo pathway is the progrowth transcriptional coactivator Yorkie [Yki-Yes-activated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) in mammals]. Yki activity is restricted through phosphorylation by the Hpo/Warts core kinase cascade, but increasing evidence indicates that core kinase-independent modes of regulation also play an important role. Here, we examine Yki regulation in the Drosophila larval central nervous system and uncover a Hpo/Warts-independent function for the tumor suppressor kinase liver kinase B1 (LKB1) and its downstream effector, the energy sensor AMP-activated protein kinase (AMPK), in repressing Yki activity in the central brain/ventral nerve cord. Although the Hpo/Warts core cascade restrains Yki in the optic lobe, it is dispensable for Yki target gene repression in the late larval central brain/ventral nerve cord. Thus, we demonstrate a dramatically different wiring of Hpo signaling in neighboring cell populations of distinct developmental origins in the central nervous system.

References

Sep 1, 1993·Cell and Tissue Research·P GreenV Hartenstein
Jul 1, 1996·The Journal of Comparative Neurology·A Younossi-HartensteinV Hartenstein
Jan 15, 1998·Nature·A HemminkiL A Aaltonen
Sep 23, 2003·Nature Cell Biology·Ryan S UdanGeorg Halder
Sep 23, 2003·Nature Cell Biology·Sophie PantalacciPierre Léopold
Nov 15, 2003·Current Biology : CB·Angela WoodsDavid Carling
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reuben J ShawLewis C Cantley
Nov 8, 2005·Cell Death and Differentiation·J H LeeJ Chung
Sep 5, 2006·Current Biology : CB·Riitta NoloGeorg Halder
Sep 19, 2006·Nature Genetics·Eunjoo ChoKenneth D Irvine
Oct 3, 2006·Developmental Cell·Wigard P Kloosterman, Ronald H A Plasterk
Dec 22, 2006·Genes & Development·Hongyan WangWilliam Chia
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ji-Wu WangBingwei Lu
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Johannes BischofKonrad Basler
Aug 7, 2007·Nature·Hongbin JiKwok-Kin Wong
Nov 6, 2007·Current Biology : CB·Fernando D CamargoThijn R Brummelkamp
Dec 26, 2007·The Journal of Biological Chemistry·Yawei HaoXiaolong Yang
Feb 8, 2008·Development·Hyangyee Oh, Kenneth D Irvine
Mar 18, 2008·Developmental Cell·Sarah K BowmanJuergen A Knoblich
Jul 22, 2008·The Journal of Biological Chemistry·Tsutomu OkaMarius Sudol
Oct 4, 2008·PLoS Genetics·Brandon N Nicolay, Maxim V Frolov
Nov 19, 2008·Genes & Development·Xinwei CaoFred H Gage
Nov 26, 2008·Oncogene·A F Hezel, N Bardeesy

❮ Previous
Next ❯

Citations

Jan 12, 2016·Trends in Cell Biology·Giulia SantinonSirio Dupont
Mar 22, 2016·Current Biology : CB·Carole L C PoonKieran F Harvey
Jun 15, 2016·Cancer Cell·Francesca ZanconatoStefano Piccolo
Apr 2, 2017·Current Opinion in Cell Biology·Helena E Richardson, Marta Portela
Nov 24, 2017·Frontiers in Cellular Neuroscience·Lili XieBing Jiang
Mar 14, 2019·CNS Neuroscience & Therapeutics·Jun HuangFang Lin
Oct 24, 2018·The EMBO Journal·Andrew G CoxWolfram Goessling
Nov 5, 2017·Oncotarget·Mingjing MengGangjun Du
Aug 31, 2018·Nature Communications·Mandeep K GillLiliana Attisano
Jul 28, 2018·Nature Cell Biology·Antonio TotaroStefano Piccolo
Sep 19, 2019·Development·John Robert Davis, Nicolas Tapon
May 28, 2020·Frontiers in Cell and Developmental Biology·Karishma GangwaniMadhuri Kango-Singh
Apr 1, 2018·Cellular and Molecular Life Sciences : CMLS·Sungho MoonHyun Woo Park
Apr 10, 2019·Journal of Translational Medicine·Yanyan Han
Aug 6, 2019·Frontiers in Bioengineering and Biotechnology·David Wu, Konstantin Birukov
Dec 20, 2018·Annual Review of Biochemistry·Shenghong MaKun-Liang Guan
May 2, 2019·Therapeutic Advances in Medical Oncology·Shuren WangNingzhi Xu
Dec 5, 2020·Developmental Neurobiology·Manas Ranjan Sahu, Amal Chandra Mondal
Feb 8, 2020·Developmental Cell·Lauren K TyraHelmut Krämer
May 25, 2020·Trends in Cancer·Aishwarya KulkarniKieran F Harvey
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Yong Suk Cho, Jin Jiang
Jul 22, 2020·Developmental Cell·Consuelo Ibar, Kenneth D Irvine
Jul 29, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tapan BehlSimona Bungau
Jan 6, 2016·Genes & Development·Zhipeng MengKun-Liang Guan
Aug 7, 2019·Developmental Cell·Yonggang Zheng, Duojia Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecular Biology International
Francesca FaustiGiovanni Blandino
Developmental Cell
Jennifer L Bandura, Bruce A Edgar
International Journal of Gastrointestinal Cancer
Dora M Lam-HimlinRobert A Anders
© 2021 Meta ULC. All rights reserved