Differential Corticomotor Excitability Responses to Hypertonic Saline-Induced Muscle Pain in Forearm and Hand Muscles

Neural Plasticity
Dennis B LarsenS Boudreau

Abstract

Experimental muscle pain inhibits corticomotor excitability (CE) of upper limb muscles. It is unknown if this inhibition affects overlapping muscle representations within the primary motor cortex to the same degree. This study explored CE changes of the first dorsal interosseus (FDI) and extensor carpi radialis (ECR) muscles in response to muscle pain. Participants (n = 13) attended two sessions (≥48 hours in-between). Hypertonic saline was injected in the ECR (session one) or the FDI (session two) muscle. CE, assessed by transcranial magnetic stimulation (TMS) motor-evoked potentials (MEPs), was recorded at baseline, during pain, and twenty minutes postinjection together with pain intensity ratings. Pain intensity ratings did not differ between the two pain sites (p = 0.19). In response to FDI muscle pain, the MEPs of the FDI muscle were reduced at 2 and 4 min postinjection (p ≤ 0.03), but not after ECR muscle pain. No significant MEP change was detected for the ECR muscle (p = 0.62). No associations between MEPs and pain intensity were found (p > 0.2). The present results indicate that the output from overlapping cortical representations of two muscles differentially adapts to acute muscle pain.

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Citations

Nov 15, 2019·Journal of Applied Physiology·Christopher LatellaJanet L Taylor
Jun 22, 2020·Experimental Brain Research·Simon J SummersLucy S Chipchase
Jun 4, 2019·Medicine and Science in Sports and Exercise·Lucas StefanelliDuane C Button
Feb 7, 2021·The Journal of Pain : Official Journal of the American Pain Society·David A RicePeter J McNair
Dec 29, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Rocco CavaleriSiobhan M Schabrun
Feb 12, 2021·Journal of Applied Physiology·Christopher LatellaJanet L Taylor

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