Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors

Journal of Ovarian Research
Alicia Beeghly-FadielDineo Khabele

Abstract

High cyclooxygenase (COX)-2 expression in ovarian tumors has been associated with poor prognosis, but the role of COX-1 expression and its relation to survival is less clear. Here, we evaluated COX expression and associations with survival outcomes between type I (clear cell, mucinous, low grade endometrioid and low grade serous) and type II (high grade serous and high grade endometrioid) ovarian tumors. We developed and validated a new COX-1 antibody, and conducted immunohistochemical (IHC) staining for COX-1 and COX-2 on a tissue microarray (TMA) of 190 primary ovarian tumors. In addition to standard IHC scoring and H-scores to combine the percentage of positive cells and staining intensity, we also measured COX-1 and COX-2 mRNA expression by QPCR. High expression was defined as greater than or equal to median values. Clinical characteristics and disease outcomes were ascertained from medical records. Associations with disease-free survival (DFS) and overall survival (OS) were quantified by hazard ratios (HRs) and confidence intervals (CIs) from proportional hazards regression. Type I tumors had high COX-2 expression, while type II tumors had high COX-1 expression. In multivariable adjusted regression models, higher COX-1 mRN...Continue Reading

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Citations

Oct 21, 2018·Journal of Cellular Physiology·Nasser Hashemi GoradelKeywan Mortezaee
Jul 28, 2019·Cancers·Laurie G HudsonAngela Wandinger-Ness
Sep 29, 2020·Frontiers in Pharmacology·Paige G SmithJocelyn C Reader
Aug 8, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mollie E BarnardShelley S Tworoger
Mar 14, 2021·Annals of Diagnostic Pathology·Marwa Mohammed DawoudMohammad Ibrahim Shaban
Oct 22, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marwa M DawoudEnas Ab B Elkhouly
Sep 27, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Amanda J BoyleNeil Vasdev

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Methods Mentioned

BETA
PCR
ELISA
affinity purification
RNA-seq

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