Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin.

Journal of Cellular and Molecular Medicine
W Wagner, M Wehrmann

Abstract

Wound-healing mechanisms change during transition from prenatal to postnatal stage. Cytokines are known to play a key role in this process. The current study investigated the differential cytokine activity and healing morphology during healing of incisional skin wounds in rats of the ages neonatal (p0), 3 days old (p3) and adult, after six different healing times (2 hrs to 30 days). All seven tested cytokines (Transforming Growth Factor (TGF) alpha, TGFbeta1, -beta2 and -beta3, IGF 1, Platelet Derived Growth Factor A (PDGF A), basic Fibroblast Growth Factor (bFGF) exhibited higher expression in the adult wounds than at the ages p0 and p3. Expression typically peaked between 12 hrs and 3 days post-wounding, and was not detectable any more at days 10 and 30. The neonate specimen showed more rapid re-epithelialization, far less inflammation and scarring, and larger restitution of original tissue architecture than their adult counterparts, resembling a prenatal healing pattern. The results may encourage the use of neonatal rat skin as a wound-healing model for further studies, instead of the more complicated prenatal animal models. Secondly, the data may recommend inhibition of PDGF A, basic FGF or TGF-beta1 as therapeutic targets ...Continue Reading

References

Jan 1, 1992·Plastic and Reconstructive Surgery·L BoonR Vanwijck
Sep 1, 1991·Developmental Biology·D J Whitby, M W Ferguson
Jan 1, 1994·Annals of Surgery·M T LongakerN S Adzick
Mar 1, 1993·Annals of Plastic Surgery·G G HallockB R DiPaolo
Mar 1, 1997·Journal of Pediatric Surgery·D L CassN S Adzick
Aug 11, 1998·Clinics in Plastic Surgery·R J MackoolM T Longaker
Aug 12, 1998·The Journal of Surgical Research·K W LiechtyN S Adzick
May 26, 1999·Current Topics in Pathology. Ergebnisse Der Pathologie·J M DavidsonS I Benn
Feb 24, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J M DavidsonS A Eming
Nov 8, 2001·Plastic and Reconstructive Surgery·V K Rumalla, G L Borah
Jan 12, 2002·Plastic and Reconstructive Surgery·Steven R BeanesH Peter Lorenz
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W WagnerH P Zenner
Jun 11, 2002·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Braun-Falco
Jul 12, 2002·Nature·Bruce A Sullenger, Eli Gilboa
Jan 31, 2003·World Journal of Surgery·Kelli M BullardH Peter Lorenz
Mar 15, 2003·Clinics in Plastic Surgery·Catherine DangH Peter Lorenz
Apr 25, 2003·Plastic and Reconstructive Surgery·Catherine M DangH Peter Lorenz
Jun 26, 2003·The Surgical Clinics of North America·Kevin J Cross, Thomas A Mustoe
Dec 5, 2003·Cell and Tissue Research·Michiko KoizumiSetsunosuke Ihara
Jan 22, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Wei ChenZhiyong Sheng

❮ Previous
Next ❯

Citations

Jul 14, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kjell Olmarker
Oct 14, 2008·Annals of Biomedical Engineering·Tracy Jane Stefonek-Puccinelli, Kristyn S Masters
Jun 22, 2012·European Journal of Cell Biology·Paola ZigrinoCornelia Mauch
Nov 1, 2013·Brazilian Dental Journal·Fernando Antônio Mauad de AbreuJosé Bento Alves
Jan 30, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Changyao LvHongbo He
Oct 12, 2013·Journal of Basic and Clinical Physiology and Pharmacology·Mohammed A AlzoghaibiAhmad M Zubaidi
Jan 29, 2016·Molecular Medicine Reports·Lingxia PangLingjian Wu
Oct 15, 2020·Journal of Cell Communication and Signaling·Naresh Kumar RajendranHeidi Abrahamse
Oct 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Joo YangKi Woo Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
transfection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.