PMID: 2123406Nov 12, 1990Paper

Differential dependence on protein kinase C of arachidonic acid metabolism stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage

Biochimica Et Biophysica Acta
P H SpornM Peters-Golden

Abstract

The dependence on protein kinase C (PKC) of arachidonic acid (AA) metabolism stimulated by the biologically important oxidant H2O2, as compared to zymosan particles, was investigated in the rat alveolar macrophage. The PKC inhibitor staurosporine markedly reduced AA release and eicosanoid synthesis stimulated by zymosan, but only slightly inhibited AA release and metabolism induced by H2O2. Furthermore, in macrophages depleted of PKC by extended exposure to phorbol 12-myristate 13-acetate, AA release in response to zymosan was greatly inhibited, whereas that stimulated by H2O2 was attenuated to a significantly lesser degree. Thus, zymosan-stimulated AA metabolism requires active PKC, whereas H2O2-induced metabolism is largely PKC-independent. This provides direct evidence for the existence of two pathways of agonist-stimulated AA metabolism, which differ in their dependence on PKC, in the alveolar macrophage.

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Citations

Feb 21, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·O M AtruzA G Chuchalin
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·D E HallahanR R Weichselbaum
Oct 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B Sochanowicz, I Szumiel
Nov 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K L Fritsche, N A Cassity
Jul 16, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michael Joseph CoffeyMarc Peters-Golden
Oct 1, 1993·European Journal of Biochemistry·A Huwiler, J Pfeilschifter
Feb 14, 2006·American Journal of Respiratory Cell and Molecular Biology·Megan N BallingerBethany B Moore
Jan 24, 2008·Industrial Health·Daniela PelclováPavlína Klusácková
Mar 4, 2008·American Journal of Respiratory Cell and Molecular Biology·Linda A Tephly, A Brent Carter

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