PMID: 8951423Dec 1, 1996Paper

Differential depletion of human respiratory tract antioxidants in response to ozone challenge

Free Radical Research
I MudwayF J Kelly

Abstract

The toxicity of ozone, the major component of photochemical smog, is related to its powerful oxidising ability, and many of its deleterious effects are mediated through free radical reactions. As the majority of ozone oxidation events are thought to be confined to the pulmonary epithelial lining fluid, we studied the interaction of ozone with a range of small molecular weight antioxidants found within this compartment: ascorbic acid (AH2), uric acid (UA), and reduced glutathione (GSH). Epithelial lining fluid obtained as bronchoalveolar lavage (BAL) fluid, was taken from 16 male subjects and the antioxidant concentrations determined for each subject. BAL fluid samples from nine of these subjects were then exposed, using an interfacial exposure system, to a range (50-1000 ppb) of ozone concentrations. Both AH2 and UA were consumed by ozone in a time and ozone concentration dependent manner, with mean consumption rates of 1.7 +/- 0.8 and 1.0 +/- 0.5 pmol L-1 s-1 ppb-1, respectively. Considerable intersubject variation was however observed. The individual rates of consumption for each antioxidant were significantly correlated with the respective initial antioxidant concentration. In contrast, although GSH was consumed at 50 ppb oz...Continue Reading

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Citations

May 28, 2010·American Journal of Psychoanalysis·Ken Robinson
Feb 20, 1999·Archives of Environmental Health·M SaintotM Gerber
Aug 21, 2014·Oxidative Medicine and Cellular Longevity·Borut Poljšak, Rok Fink
Aug 26, 2010·Inhalation Toxicology·Allen S LefohnWilliam C Adams
May 23, 2009·Inhalation Toxicology·Annelie F BehndigIan S Mudway
Jul 10, 2013·Journal of Applied Toxicology : JAT·Julie E GoodmanSonja N Sax
Sep 30, 2004·Free Radical Biology & Medicine·Bettina C SchockCarroll E Cross
Jun 9, 2006·Archives of Biochemistry and Biophysics·Sanaz KermaniJames S Ultman
Mar 26, 2013·The Korean Journal of Internal Medicine·Min-Sung LeeAn-Soo Jang
Feb 18, 1998·Toxicology and Applied Pharmacology·I S Mudway, F J Kelly
Apr 26, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Joseph M RutkowskiJames S Ultman
Mar 9, 2005·Respiration; International Review of Thoracic Diseases·An-Soo JangChoon-Sik Park
Aug 30, 2016·Inhalation Toxicology·Robyn L Prueitt, Julie E Goodman
Feb 26, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Blomberg
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May 28, 2020·Critical Reviews in Toxicology·Sonika Patial, Yogesh Saini
Jun 25, 1998·The American Journal of Physiology·E M PostlethwaitW A Pryor
Feb 22, 2003·Pediatric Research·Bettina C SchockMadeleine Ennis

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