Differential diagnosis of adenoid cystic carcinoma from pleomorphic adenoma of the salivary gland on fine needle aspiration cytology

Acta Cytologica
S S LeeE K Ham

Abstract

To evaluate the distinguishing morphologic features of pleomorphic adenoma and adenoid cystic carcinoma on fine needle aspiration cytology. A retrospective study was undertaken to compare the cytomorphology of 9 adenoid cystic carcinomas with that of 12 pleomorphic adenomas of the salivary gland among histologically proven cases. The most consistent finding for differentiating adenoid cystic carcinoma from pleomorphic adenoma in our study was the amount of cytoplasm of individual tumor cells. Plasmacytoid appearance is a reliable finding for pleomorphic adenoma, and it enables us to rule out adenoid cystic carcinoma. All 12 cases of pleomorphic adenoma showed tumor cells containing abundant cytoplasm in clusters and isolated cells, with plasma cell-like appearance in 9 cases, especially in isolated cells. In contrast with pleomorphic adenoma, most adenoid cystic carcinomas showed little cytoplasm. Hyaline spherical globules were found in four of nine adenoid cystic carcinomas but were not found in any case of pleomorphic adenoma. It was specific but not sensitive to adenoid cystic carcinoma. Fibrillary chondromyxoid ground substance and a mixture of epithelial cells with stroma were found in two-thirds of the pleomorphic adenom...Continue Reading

Citations

Jun 3, 1999·Diagnostic Cytopathology·H NagelM Droese
Dec 23, 2015·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Niti SinghalVikas Gupta
Nov 1, 2008·Diagnostic Cytopathology·Uma HandaHarsh Mohan
Sep 3, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kanwar Deep Singh NandaJasmine Nanda
Jun 27, 2013·The Laryngoscope·Chase M HeatonDavid W Eisele
Jun 18, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Katya Pulido DíazPablo Agustin Vargas
Jul 16, 2015·Diagnostic Cytopathology·Surbhi GoyalPreeti Diwaker
Jan 24, 2015·Seminars in Diagnostic Pathology·Marc P Pusztaszeri, William C Faquin
Nov 6, 2015·Cancer Cytopathology·Marc P PusztaszeriWilliam C Faquin
Apr 16, 2002·Cytopathology : Official Journal of the British Society for Clinical Cytology·Kusum Verma, Kusum Kapila
Mar 25, 2005·Cytopathology : Official Journal of the British Society for Clinical Cytology·D K Das, J T Anim
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael W Stanley
Nov 7, 2006·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·S ElagozI Arslan
Jan 17, 2013·Korean Journal of Pathology·Hye Jung JoHye-Kyoung Yoon
Apr 16, 2017·Diagnostic Cytopathology·Christopher C GriffithAlessandra C Schmitt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.