Differential diagnosis of AH109A tumor and inflammation by radioscintigraphy with L-[methyl-11C]methionine

Japanese Journal of Cancer Research : Gann
K KubotaK Ishiwata

Abstract

For the evaluation of tumor imaging with L-[methyl-11C]methionine (11C-Met), a basic study on the differentiation of tumor from inflammation with 11C-Met and a comparison of the diagnostic value of the image with that obtained using 67Ga citrate, a conventional scintigraphic agent, are important. 11C-Met accumulations into inflammatory lesions, AH109A tumor and normal tissues of rats were examined by means of a tissue distribution study. Aseptic inflammatory lesions on the back of Donryu rats induced by croton oil and 1.5% carrageenan showed significantly lower accumulations of 11C-Met than the AH109A tumor. Histologically, croton oil induced granulomatous inflammation and carrageenan, acute exudative inflammation. Whole-body autoradiography with 14C-Met, a substitute for 11C-Met, was negative in the carrageenan lesion and showed a slightly increased activity at the periphery of the croton oil lesion, in contrast with the high tumor activity. Whole-body autoradiography with 67Ga citrate was performed to compare the imaging ability with that of 14C-Met; it showed high activities in the tumor, bone, and intestine, and a broad increased activity at the periphery of the croton oil lesion, but was negative in the carrageenan lesion....Continue Reading

References

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Citations

Nov 3, 2009·Cancer Biotherapy & Radiopharmaceuticals·Deepa SinhaAnil K Mishra
Jul 29, 2003·Head & Neck·Jurjan R De BoerBernard F A M Van Der Laan
Apr 23, 2009·Molecular Oncology·Leonard Fass
Dec 14, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Songji ZhaoNagara Tamaki
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Christophe Van de WieleRudi Andre Dierckx
Oct 31, 2006·Academic Radiology·Alper O KaracaliogluE Edmund Kim

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