Differential diagnosis of parkinsonism with [18F]fluorodeoxyglucose and PET

Movement Disorders : Official Journal of the Movement Disorder Society
A AntoniniD Eidelberg

Abstract

The clinical differentiation between typical idiopathic Parkinson's disease (IPD) and atypical parkinsonian disorders (APD) is complicated by the presence of signs and symptoms common to both forms of parkinsonism. Metabolic brain imaging with [18F]fluorodeoxyglucose (FDG) and positron emission tomography (PET) may be a useful adjunct in differentiating APD from IPD. To explore this possibility, we studied 48 parkinsonian patients suspected as having possible APD because of a deteriorating response to dopaminergic treatment, the development of autonomic dysfunction, or both. A group of 56 patients with likely IPD served as control subjects. We used quantitative FDG/PET to measure regional rates of cerebral glucose use in IPD and APD patients. We used discriminant analysis to categorize IPD and APD patients based on their regional metabolic data. We found that a linear combination of caudate, lentiform, and thalamic values accurately discriminated APD from IPD patients (p < 0.0001). Significant metabolic abnormalities were present in the striatum and the thalamus of 36 of 48 (75%) APD patients. Our findings show that measurements of regional glucose metabolism can be used to discriminate patients with suspected APD from their co...Continue Reading

References

Nov 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Dec 1, 1990·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·N Quinn
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D EidelbergS Przedborski
Dec 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·N P Quinn, C D Marsden
Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A AntoniniK L Leenders

❮ Previous
Next ❯

Citations

Mar 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·R H WalkerC W Olanow
May 29, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·H H FernandezM Rosenfeld
Apr 7, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J H Friedman, S A Factor
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J A Saint-Cyr, L L Trépanier
Jul 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Giulio CicarelliPaolo Barone
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Michele T M HuDavid J Brooks
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew FeiginDavid Eidelberg
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·P J ReadingI G McKeith
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·G BerdingW H Knapp
Jan 17, 2002·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·S Braune
Nov 15, 2005·Journal of Neural Transmission·R CiliaA Antonini
Mar 6, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yilong Ma, David Eidelberg
Jun 26, 2004·Current Neurology and Neuroscience Reports·Dennis J Zgaljardic, Andrew Feigin
Mar 23, 2004·Sleep Medicine·A AntoniniG Pezzoli
Mar 23, 2004·Sleep Medicine·Angelo Antonini, Roberta DeNotaris
Aug 23, 2001·Brain Research. Brain Research Reviews·C DavidsonE H Ellinwood
Jan 30, 2004·Lancet Neurology·Gregor K WenningWerner Poewe
May 23, 2006·Clinical Nuclear Medicine·I SarikayaO Karaoglan
Jul 12, 2008·The Neurologist·Roongroj Bhidayasiri, Helen Ling
Apr 12, 2012·Neurology·K L PostonD Eidelberg
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Eckert, David Eidelberg
Apr 15, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jean A Saint-Cyr
Feb 2, 2016·Expert Review of Neurotherapeutics·Musleh A Algarni, A Jon Stoessl
Sep 10, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yasuo TeraoYoshikazu Ugawa
Oct 10, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Christian BrenneisGregor K Wenning
Sep 8, 2011·Progress in Neurobiology·David J Brooks, Nicola Pavese
Apr 21, 2009·Medicina clínica·Marta RamírezFrancesc Graus
Dec 6, 2008·Neurologic Clinics·Robert S Miletich
Oct 31, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Shigeki HiranoDavid Eidelberg
Jan 11, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas EckertDavid Eidelberg
Jun 16, 2005·NeuroImage·Thomas EckertD Eidelberg
Dec 23, 2011·Parkinsonism & Related Disorders·David J Brooks
Jul 30, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Flavia Niccolini, Marios Politis
Jun 23, 2010·Drug and Alcohol Dependence·Yong An ChungDai Jin Kim
Oct 26, 2016·Journal of Neural Transmission·Eleonora FiorenzatoUNKNOWN Movement Disorders Society MSA (MODIMSA) Neuropsychology and Imaging Study Groups
Nov 27, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-S KimK-S Lee
Dec 20, 2005·Lancet Neurology·Eduardo TolosaWerner Poewe
Mar 6, 2018·Neurology India·Madhavi TripathiChandrasekhar Bal
May 2, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanUNKNOWN Movement Disorders Society Scientific Issues Committee
Aug 29, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Pankaj A Agarwal, A Jon Stoessl
Apr 5, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P H LeeK Huh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.