PMID: 6162619Mar 1, 1981Paper

Differential diagnosis of pleural effusions: clinical usefulness of cell marker quantitation

Chest
A O VladutiuR H Adler

Abstract

Carcinoembryonic antigen (CEA), orosomucoid beta 2 microglobulin, and alpha fetoprotein were quantified in the pleural fluid and serum of 58 hospitalized consecutive patients in order to differentiate malignant from non-malignant effusions. Cytologic examination of the effusions was also performed. The orosomucoid assay was the most helpful in identifying malignant effusions; higher values (greater than 100 mg/100 ml) were found in 74 percent (26/35) of malignant effusions. Quantitation of carcinoembryonic antigen had a high specificity (95 percent) but a low sensitivity (36 percent) for the detection of malignant pleural effusions. The parallel quantitation of CEA and orosomucoid had a higher sensitivity (86 percent) which increased when associated with cytologic examination. The sensitivity of cytology was only 46 percent. The concentrations of orosomucoid in pleural effusions correlated well with serum concentrations. Alpha fetoprotein and beta 2 microglobulin quantitations were of no clinical value for diagnosing malignant effusions. It is suggested the cytologic examination combined with orosomucoid and CEA quantitation in pleural fluid have a considerable clinical value for the diagnosis of pleural effusions.

References

Apr 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·H O AdamiG Lundqvist
Apr 1, 1979·Annals of Internal Medicine·N C ThomsonJ G Ratcliffe
May 1, 1978·Annals of Internal Medicine·R A RittgersN Zamcheck
Jul 1, 1977·Archives of Internal Medicine·J S NystromB Haverback
Jul 1, 1974·The Journal of Clinical Investigation·D RudmanJ M Conn

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Citations

Jan 1, 1987·Cancer Metastasis Reviews·F H Hausheer, J W Yarbro
Aug 29, 1997·International Journal of Cardiology·K K KohY H Lee
Sep 14, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·W DejsomritrutaiB Promkiamon
Nov 25, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeong-Seon RyuHong-Lyeol Lee
Apr 22, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Huan-Zhong ShiHai-Bo Yang
Jan 1, 1993·Postgraduate Medical Journal·N Berkman, M R Kramer
Jan 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·M RapellinoG Ricardi
Mar 1, 1997·Chest·E Garcia-PachonA Miralles-Llopis
Dec 1, 1989·Gynecologic Oncology·S KudlacekM Micksche
Jan 1, 1984·Medical and Pediatric Oncology·A G WardmanN J Cooke
Jul 1, 1986·Pathology·D WhitakerW N Nieuwhof
Jul 1, 1991·The Korean Journal of Internal Medicine·N J KimH K Ro
Jan 15, 1988·Cancer·S TamuraK Higashino
Sep 1, 1983·Cancer·K M UngerB Barlogie
Apr 1, 1984·Postgraduate Medicine·U W Rosa
Oct 1, 1986·Postgraduate Medicine·S J Jay

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