Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors

Gynecologic and Obstetric Investigation
Hüsnü GökaslanFatih Durmuşoğlu

Abstract

To investigate the expression and value for diagnosis of the genes, p53 and pTEN, the protein, Ki-67, and the receptors, estrogen and progesterone, in differentiating smooth muscle tumors of the uterus. Seventeen samples of leiomyosarcoma, 2 smooth muscle tumors with uncertain malignant potential (STUMP), 9 atypical myomas and 15 leiomyomas were stained immunohistochemically. The chi(2) test was used for the statistical analysis of the data. The malignant side of the spectrum was strongly stained for Ki-67 and p53 while uniformly decreasing toward the benign tumors. The results were found to be statistically significant (p < 0.0001). The staining for progesterone receptor was also statistically significant, but the tumors that were considered benign, such as leiomyoma and atypical myoma, were the ones strongly stained (p = 0.005). The expression of estrogen receptor was significant in these tumors, but the p value was very close to the cut-off value (p = 0.07). As the degree of differentiation of the tumor increased, the trend showed stronger staining for estrogen receptor. However, no difference was detected in the staining properties of the tumors for pTEN (p = 0.2457). The expression of Ki-67, p53 and progesterone receptors ...Continue Reading

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Citations

Dec 17, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Riitta Koivisto-KoranderArto Leminen
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cheng-Han LeeC Blake Gilks
Dec 7, 2005·The American Journal of Surgical Pathology·Nicole Nicosia EspositoMirka W Jones
May 3, 2013·Current Opinion in Oncology·Andrew J BathanRobin L Jones
Dec 29, 2007·The American Journal of Surgical Pathology·Kristen A AtkinsLaurel W Rice
Dec 3, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Xichun Sun, Khush Mittal
May 31, 2011·Journal of Medical Case Reports·Hye Sung WonKyungji Lee
Apr 14, 2012·Human Pathology·Kristine CornejoZhong Jiang
Jun 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Nil Ustündagğ ComunoğluNil Molinas
Mar 26, 2016·The American Journal of Surgical Pathology·Julianne M UbagoJian-Jun Wei
Sep 9, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Bertha DelgadoRuthy Shaco-Levy

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