Abstract
Differential diagnosis of squamous cell carcinoma in situ is of great importance for prognosis and decision making in the disease treatment procedure. Currently, differential diagnosis is done by pathologists based on examination of the histopathological slides under the microscope, which is time consuming and prone to inter and intra observer variability. In this paper, we have proposed an automated method for differential diagnosis of SCC in situ from actinic keratosis, which is known to be a precursor of squamous cell carcinoma. The process begins with epidermis segmentation and cornified layer removal. Then, epidermis axis is specified using the paths in its skeleton and the granular layer is removed via connected components analysis. Finally, diagnosis is done based on the classification result of intensity profiles extracted from lines perpendicular to the epidermis axis. The results of the study are in agreement with the gold standards provided by expert pathologists.
References
Oct 24, 2007·IEEE Transactions on Medical Imaging·Ali TabeshOlivier Saidi
Dec 11, 2007·The British Journal of Dermatology·J Roewert-HuberH Kerl
Feb 6, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·T F Chan, L A Vese
Jan 24, 2009·IEEE Transactions on Medical Imaging·Po-Whei Huang, Cheng-Hsiung Lee
Mar 24, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Alexandros T TzallasDimitrios I Fotiadis
Jul 29, 2010·Computer Methods and Programs in Biomedicine·Qaisar AbbasMuhammad Rashid
Feb 8, 2011·IEEE Transactions on Bio-medical Engineering·M Murat DundarMetin N Gurcan
Oct 28, 2011·Micron : the International Research and Review Journal for Microscopy·M Muthu Rama KrishnanChandan Chakraborty
May 23, 2012·IEEE Journal of Biomedical and Health Informatics·Cheng LuMrinal Mandal
Oct 16, 2012·Artificial Intelligence in Medicine·Konstantin Korotkov, Rafael Garcia
Nov 3, 2012·Computers in Biology and Medicine·N M ShakyaW V Stoecker
Dec 19, 2013·PloS One·Xavier Moles LopezChristine Decaestecker
Feb 25, 2014·Computers in Biology and Medicine·Saima RathoreAbdul Jalil
Apr 25, 2014·IEEE Transactions on Bio-medical Engineering·Mitko VetaMax A Viergever
May 6, 2014·Micron : the International Research and Review Journal for Microscopy·Mojgan MokhtariVahid Malekian
Sep 6, 2014·IEEE Journal of Biomedical and Health Informatics·Hongming XuMrinal Mandal
Jun 24, 2015·Micron : the International Research and Review Journal for Microscopy·Navid Noroozi, Ali Zakerolhosseini
Citations
May 21, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Carolina MagalhaesRicardo Vardasca
Mar 15, 2020·Sensors·Dariusz KucharskiMarek Gorgon
Aug 28, 2021·Diagnostics·Mohamed A KassemMohamed Meselhy Eltoukhy