Differential diagnostic value of GPC3-CD34 combined staining in small liver nodules with diameter less than 3 cm

American Journal of Clinical Pathology
Fengmei WangZhi Du

Abstract

The diagnostic value of combining glypican-3 (GPC3) and CD34 staining for small nodules in liver biopsy specimens has not been evaluated. In this study, 201 thin-core biopsy specimens were assessed using GPC3 and CD34 immunochemical staining, including 33 cirrhotic regenerative nodules, 31 high-grade dysplastic nodules, 70 hepatocellular carcinomas (HCCs) with nodules 3 cm or smaller, and 67 HCCs with nodules larger than 3 cm. The results showed that the accuracy of GPC3 staining (90.3%) among liver nodules 3 cm or smaller was better than its use among all nodules (P = .045). Furthermore, the positive expression rate of costaining was significantly greater than that observed for GPC3 or CD34 single staining (P < .001 and P = .002, respectively). These data demonstrate that GPC3 staining is more accurate for the diagnosis of HCC on thin-core biopsy specimens in nodules 3 cm or smaller compared with its use in all nodules, while GPC3 and CD34 costaining has better diagnostic value than does single staining.

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Citations

Oct 22, 2013·FEBS Letters·Mingqian Feng, Mitchell Ho
Jun 29, 2013·Journal of Vascular and Interventional Radiology : JVIR·Dustyn MarshallRobert K Kerlan
Jun 1, 2013·Surgical Pathology Clinics·Esmeralda Celia MargineanDhanpat Jain
Jan 12, 2013·The FEBS Journal·Jorge Filmus, Mariana Capurro
May 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying LiuGuangrong Huang
Aug 19, 2014·World Journal of Gastroenterology : WJG·Li-Li HanKe-Jun Nan
Oct 10, 2014·Advances in Anatomic Pathology·Sean K WangXiming J Yang
Dec 5, 2014·World Journal of Gastroenterology : WJG·Manuel SchlageterPaolo Sorrentino
Jun 25, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Rania Elsayed Wasfy, Aliaa Atef Shams Eldeen
Mar 23, 2017·World Journal of Hepatology·Preeyanat Vongchan, Robert J Linhardt
Mar 24, 2018·Indian Journal of Pathology & Microbiology·Monika Vyas, Dhanpat Jain
Sep 2, 2020·Journal of Gastroenterology and Hepatology·Yoshio ShimizuNobuhiro Ohkohchi

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