Differential distribution and regulation of galanin receptors- 1 and -2 in the rat lumbar spinal cord

Brain Research
P BrumovskyT Hökfelt

Abstract

The expression of the galanin receptor-1 and -2 (Gal(1) and Gal(2)) messenger ribonucleic acids (mRNAs) was studied in the lower spinal cord of rat by means of in situ hybridization, using ribonucleic acid probes (riboprobes). Naïve rats as well as rats with unilateral axotomy of the sciatic nerve or unilateral inflammation of the hindpaw were analyzed. In naïve rats, numerous Gal(1) mRNA-positive (+) neurons were detected in lamina (L) I-III. In addition, several Gal(1) mRNA(+) neurons were seen in deeper layers, including the ventral horns, area X, and the lateral spinal nucleus. In contrast, few and comparatively weakly labeled Gal(2) mRNA(+) neurons were observed, mostly in the ventral horns and in area X, with fewer in the dorsal horn and in the sympathetic and parasympathetic intermediate lateral cell columns. Axotomy induced a strong increase in intensity and number of Gal(2) mRNA(+) motoneurons ipsilateral to the lesion. In contrast, nerve cut or hindpaw inflammation did not alter the expression of Gal(1) or Gal(2) in the dorsal horn. The present (and previous) results suggest that galanin, acting through Gal(1) and Gal(2) receptors, has a modulatory role on spinal excitability, not only via interneurons in superficial ...Continue Reading

References

Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·E Habert-OrtoliJ F Mayaux
Jun 1, 1993·Progress in Neurobiology·I MerchenthalerA Negro-Vilar
Jan 1, 1995·Journal of Molecular Neuroscience : MN·M C BurgevinE Habert-Ortoli
Mar 22, 1996·Neuroreport·E L GustafsonT A Branchek
Dec 28, 1995·Brain Research. Molecular Brain Research·E M ParkerM E Goldstein
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·Z Q XuT Hökfelt
Feb 3, 1999·Annals of the New York Academy of Sciences·T BranchekM W Walker
Feb 26, 2000·Trends in Pharmacological Sciences·T A BranchekM W Walker
Sep 8, 2000·Neuroreport·R Suzuki, A H Dickenson
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·F E HolmesD Wynick
Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Jul 20, 2002·Pain·Sarah J L FlattersAnthony H Dickenson
Aug 31, 2002·Science·William A Truitt, Lique M Coolen
Sep 5, 2002·The Journal of Comparative Neurology·Thomas PhamCatia Sternini
Oct 9, 2002·Trends in Pharmacological Sciences·Hong-Xiang Liu, Tomas Hökfelt
Oct 31, 2002·Journal of Chemical Neuroanatomy·Françoise MennickenDajan O'Donnell
Sep 22, 1995·Regulatory Peptides·J N Crawley
May 20, 2003·The European Journal of Neuroscience·Stefan GrassZsuzsanna Wiesenfeld-Hallin
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·Maria E Vrontakis
Mar 3, 2004·Molecular Interventions·Scott E CountsElliott J Mufson
Jul 28, 2004·Pain·Juan Miguel Jimenez-AndradeSusan M Carlton
Apr 7, 2005·Behavioral and Cognitive Neuroscience Reviews·John K Robinson
Jul 27, 2005·Neuropeptides·Laura AnselmiCatia Sternini

❮ Previous
Next ❯

Citations

Feb 9, 2012·Pain Research and Treatment·Richard P HulseDavid Wynick
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Jan 16, 2007·Trends in Pharmacological Sciences·Pablo BrumovskyTomas Hökfelt
Aug 21, 2015·Molecular and Cellular Neurosciences·Niall KerrDavid Wynick
Feb 7, 2012·European Journal of Pharmacology·Xiaofeng XuZhenzhong Li
Apr 29, 2015·Nature Communications·Christina Springstead ScanlonNisha J D'Silva
Nov 19, 2014·PloS One·Diana AmorimFilipa Pinto-Ribeiro
Dec 22, 2016·The European Journal of Neuroscience·Natalie Kozyrev, Lique M Coolen
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Felix LockerSebastien Couillard-Despres
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.