Differential distribution and subcellular localization of ryanodine receptor isoforms in the chicken cerebellum during development

Brain Research
Y OuyangM H Ellisman

Abstract

The distribution of ryanodine receptor (RyR) isoforms was examined using isoform-specific monoclonal antibodies in the developing chicken brain, from E18 through adulthood, using light and electron microscopic immunocytochemistry. Monoclonal antibody 110F is specific for the alpha-skeletal muscle form of RyR, while monoclonal antibody 110E recognizes both the beta-skeletal muscle and cardiac isoforms, but does not distinguish between the two. Significant differences in the distribution of the alpha- and beta/cardiac forms were observed. Labeling for the alpha-form was restricted to cerebellar Purkinje neurons while the beta/cardiac form was observed in neurons throughout the brain. A major finding was the presence of labeling for the beta/cardiac in presynaptic terminals of the parallel fibers in the molecular layer and the mossy fiber terminals in the granular layer glomeruli in late development and during adulthood. Labeling for the beta/cardiac, but not the alpha-form, underwent a major redistribution in the cerebellum during the course of development. At 1 day of age, beta/cardiac labeling was present mainly in Purkinje neurons. From 1 day to 4 weeks, immunolabeling for the beta/cardiac form gradually disappeared from Purki...Continue Reading

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Citations

Apr 23, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R RahamimoffS G Kachalsky
Nov 16, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marina MatyashHelmut Kettenmann
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Aug 24, 2007·The European Journal of Neuroscience·Daisuke SuzukiTomoyuki Takahashi
Sep 2, 2008·Molecular Neurobiology·Zhao-Wen Wang
Jan 5, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C Franzini-Armstrong
May 26, 2006·Journal of Cell Science·Spyros ZissimopoulosF Anthony Lai
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Jul 26, 2003·Progress in Neurobiology·Ron BouchardJonathan D Geiger
Dec 13, 2003·Cell Calcium·Andreas BeckJoachim W Deitmer

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