PMID: 9545087Apr 17, 1998Paper

Differential distribution of beta-dystroglycan in rabbit and rat retina

Journal of Neuroscience Research
P KoulenS Kröger

Abstract

The distribution of the dystrophin-associated glycoprotein complex was investigated in rabbit and rat retina by using the monoclonal antibody 43DAG/8D5, which specifically recognizes beta-dystroglycan, a central component of the complex. In cryostat sections of retinae from both species, the authors observed staining of blood vessels, continuous labeling around the vitreal border, and strong immunoreactivity in the outer plexiform layer (OPL). Electron microscopy showed that the immunoreactivity associated with the vitreal border of the retina was the result of a subcellular concentration of beta-dystroglycan in the endfeet of Müller glial cells. A similar concentration was observed in endfeet of perivascular astrocytes in the region of contact with the capillary basal lamina. In the OPL, beta-dystroglycan was associated with the terminals of both rods and cones. The label was almost exclusively found outside the synaptic area and was particularly strong in the extensions of the photoreceptor terminals protruding into the OPL. In the OPL of the rabbit retina, the authors found additional immunoreactivity associated with the tips of postsynaptic horizontal and bipolar cell processes. These results show that the dystrophin-associ...Continue Reading

Citations

Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jakob S SatzKevin P Campbell
Aug 5, 2010·The Journal of Biological Chemistry·Motoi KanagawaTatsushi Toda
Nov 22, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Richard MilnerGregory J del Zoppo
Oct 21, 1999·Molecular Genetics and Metabolism·D A Pillers
Jan 13, 2006·Developmental Biology·Andrea LunardiLuciana Dente
Jun 6, 2003·The European Journal of Neuroscience·Frank MüllerU Benjamin Kaupp
May 21, 1999·The European Journal of Neuroscience·M BlankS Kröger
Jul 11, 2000·The Journal of Comparative Neurology·H HeringS Kröger
Jul 13, 2000·Microscopy Research and Technique·C W Morgans
Oct 13, 2017·The Journal of Comparative Neurology·Dale D HunterWilliam J Brunken
Feb 25, 2005·The Journal of Biological Chemistry·Yougen ZhanSalvatore Carbonetto
Nov 18, 1998·Current Opinion in Cell Biology·M DurbeejK P Campbell
Jun 9, 2005·Neuromuscular Disorders : NMD·Agnès BordaisAlvaro Rendon

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