PMID: 8968730Nov 1, 1996Paper

Differential distribution of endothelin peptides and receptors in human adrenal gland

The Histochemical Journal
A P DavenportC Plumpton

Abstract

Sub-type selective ligands revealed a differential distribution of endothelin (ET) receptors within human adrenal glands. High densities of ETA receptors were localized, using [125I]-PD151242, to the smooth muscle layer of the arteries, smaller vessels within the capsular plexus and to the secretory cells of zona glomerulosa (KD = 139.8 +/- 39.7, Bmax = 69.7 +/- 9.1 fmol mg-1 protein, mean of 3 individuals+/-sem). ETB receptors were present in the medulla (KD = 145.2 +/- 16.4, Bmax = 75.5 +/- 12.3), zona glomerulosa (KD = 100.6 +/- 35.1, Bmax = 63.1 +/- 10.0), fasiculata (KD 145.1 +/- 16.2, Bmax = 67.9 +/- 6.9) and reticularis (KD = 118.2 +/- 18.6, Bmax = 71.9 +/- 6.5). ETB receptors were not detected within the smooth muscle of the vasculature. Messenger RNA encoding both sub-types was present in adrenals. ET-like immunoreactivity was localized to the cytoplasm of the endothelial cells from arteries supplying the gland and resistance vessels within the capsular plexus. Staining was also detected in these cells using anti-big ET-1 and less intensely with anti-big ET-2 antisera but not within cells within the cortex or medulla. Big ET-3-like immunoreactivity was localized to secretory cells of the medulla. Staining was not found...Continue Reading

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Citations

Feb 6, 1999·European Journal of Radiology·S K MorcosJ O Karlsson
Jan 10, 1998·British Journal of Pharmacology·J J MaguireA P Davenport
Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
Mar 10, 2016·Pharmacological Reviews·Anthony P DavenportJanet J Maguire
Jan 22, 2015·Genesis : the Journal of Genetics and Development·Joseph A CacioppoCheMyong Ko
Mar 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P KorthF Pinet
May 7, 1998·Endocrine Reviews·M Ehrhart-BornsteinG P Vinson
Nov 5, 1997·The Journal of Clinical Endocrinology and Metabolism·G P RossiG G Nussdorfer
Jun 27, 2020·Biomolecular Concepts·Lucia MontiAlessandro Rossi
May 22, 1998·Journal of Cardiovascular Pharmacology·J W MockridgeA P Davenport
Oct 12, 1999·The American Journal of Physiology·A HosokawaS Satoh
Feb 12, 1998·The American Journal of Physiology·G MazzocchiG G Nussdorfer
Jan 15, 1999·Endocrine Research·M N MathieuC Chevillard
Jul 9, 2021·Biomolecular Concepts·Lucia MontiAlessandro Rossi
Aug 10, 2021·The EPMA Journal·Adriana Torres CrignaOlga Golubnitschaja

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