PMID: 9416918Jan 7, 1998Paper

Differential distribution of inositol 1,4,5-triphosphate receptors in the rat olfactory bulb

The Journal of Comparative Neurology
M L SlaweckiA Keller

Abstract

The inositol 1,4,5-triphosphate receptor (IP3R) regulates the release of calcium from intracellular stores. In the present study, the distribution of IP3R in the rat main olfactory bulb was determined by immunohistochemistry. Immunofluorescence was used to double label for IP3R and for gamma-aminobutyric acid (GABA) or for projection neurons, which were retrogradely labeled following dextran injection into the lateral olfactory tract (LOT). The expression profile of IP3R changes dramatically during development. In the glomerular layer of adults, many juxtaglomerular neurons are IP3R immunoreactive [IP3R(+)]; the majority of these cells are also GABA immunoreactive [GABA(+)]. Scattered sparsely throughout the external plexiform layer are small numbers of IP3R(+) neurons, a small number of which are LOT-projecting tufted cells. Significant numbers of IP3R(+) neurons are in the granule cell layer; however, most of these cells are GABA(-). The vast majority of mitral cells contain little or no IP3R immunoreactivity. These findings indicate that, in the olfactory bulb of adult rats, IP3R is preferentially localized in specific classes of intrinsic neurons and that it is rarely expressed in projection neurons. In contrast, during the...Continue Reading

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Citations

Dec 2, 2005·Journal of Neurophysiology·Ambarish S GhatpandeSukumar Vijayaraghavan

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