Abstract
The expression of the alpha and beta isoforms of phosphatidylinositol transfer protein (PI-TP alpha and PI-TP beta) in the adult rat brain was examined by in situ hybridization analysis with isoform-specific RNA probes. PI-TP alpha mRNA was detected in rather restricted regions of the brain whereas PI-TP beta mRNA was widely distributed in the brain. PI-TP alpha mRNA signals were remarkable in neocortex layers II/III and V/VI, Purkinje cell layer, deep cerebellar nuclei of the cerebellum, red nucleus and most part of brain stem. Low levels of PI-TP alpha transcript were present in CA3 of the hippocampus, ventral and dorsal thalamic nuclei, and motoneurons of spinal cord. No hybridization signals was obtained in the olfactory bulb, basal ganglia, amygdala, hypothalamus, and pituitary gland. In contrast, strong signals of PI-TP beta mRNA were detected in the dentate gyrus. The beta isoform mRNA was moderately expressed in olfactory bulb, layers II/III of the neocortex, striatum, CA1-CA4 regions of the hippocampus, medial habenula, cerebellum, amygdala, hypothalamus, spinal cord, and pituitary gland. Thalamus and brain stem contained relatively low, but significant levels of PI-TP beta transcript. The distinct distribution of PI-T...Continue Reading
References
Mar 1, 1977·The Journal of General Physiology·W A Harris, W S Stark
Oct 23, 1992·Science·S Nakanishi
Feb 28, 1991·Nature·M MasuS Nakanishi
Jan 1, 1991·Annual Review of Biochemistry·K W Wirtz
Feb 22, 1991·Cell·A E ClevesV A Bankaitis
Oct 11, 1990·Nature·V A BankaitisW Dowhan
Apr 1, 1989·The Journal of Cell Biology·V A BankaitisR Greene
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C A RossS H Snyder
Apr 1, 1986·Journal of Bioenergetics and Biomembranes·G M Helmkamp
Sep 18, 1987·Biochimica Et Biophysica Acta·P A Van ParidonK W Wirtz
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·Y Hotta, S Benzer
Apr 23, 1981·Biochimica Et Biophysica Acta·A M Kasper, G M Helmkamp
Oct 12, 1995·Nature·M OhashiW B Huttner
May 26, 1995·Science·A Kauffmann-ZehJ J Hsuan
Nov 21, 1994·Neuroscience Letters·O Tanaka, H Kondo
Aug 4, 1994·Biochimica Et Biophysica Acta·T B GeijtenbeekK W Wirtz
May 16, 1994·Gene·S K DickesonL R Yarbrough
Dec 9, 1993·Nature·J C Hay, T F Martin
Feb 1, 1994·The Journal of Cell Biology·T P McGeeV A Bankaitis
Sep 1, 1993·The Journal of Cell Biology·T S VihtelicD R Hyde
Sep 10, 1993·Cell·G M ThomasS Cockcroft
Dec 7, 1995·Biochimica Et Biophysica Acta·S TanakaK Hosaka
Sep 9, 1996·FEBS Letters·S TanakaK Hosaka
Jan 1, 1996·Mechanisms of Development·K OhtaH Tanaka
Citations
Jun 8, 1999·Chemistry and Physics of Lipids·S Cockcroft
May 24, 2011·Clinical Lipidology·Aaron H NileAby Grabon
Jan 14, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tatsuya ShimizuNobuhito Saito
Feb 21, 2008·Journal of Cell Science·Katharina E CoskerBritta J Eickholt