Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains

Neuroscience
D R Gehlert, S L Gackenheimer

Abstract

The distribution of neuropeptide Y Y1 and Y2 receptors has been extensively studied in the rat using selective masking of [125I]peptide YY binding by Y1- and Y2-selective peptides. In the present study, we characterized the binding of the subtype-selective radioligands [125I](Leu31-Pro34)-peptide YY and [125I]peptide YY3-36 to rat and guinea-pig brains and identified differences in Y1 and Y2 distribution. [125I](Leu31Pro34)-peptide YY and [125I]peptide YY3-36 bound to single sites in rat and guinea-pig brains with pharmacologies consistent with the Y1 and Y2 receptors, respectively. Autoradiographic studies were conducted using adjacent sections from rat and guinea-pig brains. Compared to the rat, the distribution of both Y1 and Y2 receptors was markedly different in the guinea-pig. For example, a high level of Y1 binding was detected within the thalamus of the rat while, in the guinea-pig, very little Y1 binding was observed in this region. Y1 binding was very low in the rat hippocampus, while the guinea-pig hippocampus contained high levels of Y1 binding. High levels of both Y1 and Y2 binding were observed in the guinea-pig cerebellum while, in the rat, only low levels of Y2 binding were visible. Therefore, the guinea-pig bra...Continue Reading

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Citations

Oct 31, 2002·Human Psychopharmacology·Michael Maes
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