Differential distribution of parvalbumin immunoreactive neurons in the striatum of cocaine sensitized rats

Neuroscience
M S TodtenkopfD S Zahm

Abstract

Intermittent administration of psychostimulants such as cocaine and amphetamine can result in behavioral sensitization, which is believed to model the onset of drug addiction, as well as possible neural adaptations that lead to addictive behaviors. The dorsal striatum and the nucleus accumbens (NAc) have been shown to play an integral role in this phenomenon. However, these structures comprise a complex neuroanatomical organization, and few studies have correlated anatomical differentiation within these brain regions with functional (i.e. behavioral) outcome, particularly after psychostimulant exposure. Parvalbumin (PV)-containing GABAergic interneurons are a key neuronal cell population that can significantly regulate input-output functions in these brain regions. The present study quantified parvalbumin-immunoreactive cells in subterritories of the striatum and NAc in animals behaviorally sensitized to cocaine. Rats received a sensitization-inducing regimen of cocaine (twice-daily injections of 15 mg/kg i.p. for 5 consecutive days). Two or 14 days following the last injection, rats were given a challenge injection of cocaine (15 mg/kg i.p.), and killed 2 h later. Sections through the striatum (including the NAc) were processe...Continue Reading

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Citations

Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Paul S A KalanithiFlora M Vaccarino
Dec 8, 2004·Biochemical and Biophysical Research Communications·Mijung YeomDae-Hyun Hahm
Aug 30, 2005·Neuroscience and Biobehavioral Reviews·Daniel S Zahm
Jan 27, 2015·The International Journal of Neuropsychopharmacology·Felipe V GomesFrancisco S Guimarães
May 18, 2016·Neurotoxicity Research·Siriluk VeerasakulSutisa Nudmamud-Thanoi
Feb 10, 2010·Journal of Psychopharmacology·Regina TaurinesJohannes Thome
Aug 26, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaoting WangAnne E West
Mar 7, 2018·Neuroscience Bulletin·Rong-Jun NiJiang-Ning Zhou
May 29, 2018·The Journal of Physiology·Patricia MonteiroGuoping Feng
May 28, 2019·Molecular Neurobiology·Julianna KardosLászló Héja
Sep 14, 2019·Behavioural Brain Research·Ewa Siucinska
Jul 6, 2021·Frontiers in Psychiatry·Lailun NaharHyung W Nam

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