Differential distribution of probenecid as detected by on-tissue mass spectrometry

Cell and Tissue Research
Yulin QiDietrich A Volmer

Abstract

We demonstrate, by means of on-tissue mass spectrometry of tissue sections, that the drug probenecid can penetrate the blood-brain barrier. This method holds general promise for the detection and distribution of small molecule drugs within organ and tissue compartments.

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Citations

Jan 31, 2017·The Journal of Allergy and Clinical Immunology·Tomoki FukuyamaWolfgang Bäumer
Nov 2, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Waleed Elsayed Ahmed EllawattyYukio Kato

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